INT135299

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 12.16
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTCH1) Golgi apparatus (PTCH1) plasma membrane (PTCH1)
Anatomy Link Frequency
perineum 1
PTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 10 99.90 Very High Very High Very High
antagonist 2 90.52 High High
headache 8 12.88 Low Low
imagery 24 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
Hsan 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
local anesthetic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Basal Cell Nevus Syndrome 372 100.00 Very High Very High Very High
Medulloblastoma 124 99.98 Very High Very High Very High
Basal Cell Carcinoma 202 99.76 Very High Very High Very High
Breast Cancer 220 98.08 Very High Very High Very High
Cancer 348 97.76 Very High Very High Very High
Syndrome 162 96.20 Very High Very High Very High
Rhabdomyosarcoma 20 93.44 High High
Glioma 2 92.88 High High
Fibroma 48 92.40 High High
Odontogenic Cysts 96 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Table 5 indicates significant association between alterations of FANCC (P = 0.004) and PTCH1 (P = 0.001) genes with their protein expression as seen by immunohistochemistry.
PTCH1 Binding (association) of
1) Confidence 0.48 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.43 Pain Relevance 0
SMO is a transmembrane protein that localizes to the cell membrane when hedgehog (Hh) ligands (Sonic, Indian, or Desert Hh) bind to cell surface receptor Patched1 (Ptch1).
Patched1 Binding (bind) of
2) Confidence 0.40 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.58 Pain Relevance 0.05
Overall alterations of PTCH1 showed significant association with XPA in both group-A (P = 0.003) and group-B (P = 0.007).
PTCH1 Binding (alterations) of
3) Confidence 0.37 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.34 Pain Relevance 0
Similarly, correlation between PTCH1 alterations with BRCA1 deletion in group-A suggested its association with other DNA repair pathways.
PTCH1 Binding (alterations) of
4) Confidence 0.37 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.39 Pain Relevance 0
In FANCC, both deletion and methylation showed significant association in both groups (P = 0.004 and 0.002) while, in PTCH1 significant association was observed only in group-A (P = 0.002) [data no shown].


PTCH1 Binding (association) of
5) Confidence 0.37 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.29 Pain Relevance 0
In addition, the PTCH c.3944C/C genotype was also associated with BCC risk (OR 1.94 [1.2-3.1]), especially in the subgroup of patients with multiple tumors (OR 2.16 [1.3-3.6]).
PTCH Binding (associated) of associated with cancer and basal cell carcinoma
6) Confidence 0.36 Published 2006 Journal J. Invest. Dermatol. Section Abstract Doc Link 16645598 Disease Relevance 0.89 Pain Relevance 0.37
Thus, our data show that MC1R and PTCH variants are associated with BCC risk in the French population.
PTCH Binding (associated) of associated with melanocortin 1 receptor and basal cell carcinoma
7) Confidence 0.36 Published 2006 Journal J. Invest. Dermatol. Section Abstract Doc Link 16645598 Disease Relevance 0.85 Pain Relevance 0.37
SMO is a transmembrane protein that localizes to the cell membrane when hedgehog (Hh) ligands (Sonic, Indian, or Desert Hh) bind to cell surface receptor Patched1 (Ptch1).
Ptch1 Binding (bind) of
8) Confidence 0.31 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.58 Pain Relevance 0.05
There is some evidence that medulloblastomas associated with NBCCS have a better clinical outcome than those found in isolation [47,81,82], with the possibility of spontaneous recovery [82].
NBCCS Binding (associated) of associated with basal cell nevus syndrome and medulloblastoma
9) Confidence 0.14 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 2.45 Pain Relevance 0
Wang and Goldberg reported a patient with NBCCS who developed multiple polypoid basal cell carcinomas (PBCC) in the perineum, leading to the recommendation that the perineum, perianal, and genital areas should be included in the routine examination of patients with NBCCS [24].
NBCCS Spec (examination) Binding (patient) of in perineum associated with basal cell nevus syndrome and basal cell carcinoma
10) Confidence 0.11 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 1.41 Pain Relevance 0
Medulloblastoma is frequent [44,47-55]; Herzberg and Wiskemann first pointed out the association of NBCCS with medulloblastoma in 1963 [80].
NBCCS Binding (association) of associated with basal cell nevus syndrome and medulloblastoma
11) Confidence 0.11 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 2.25 Pain Relevance 0
Many different signs and symptoms may be associated with NBCCS (Table 2).
NBCCS Binding (associated) of associated with basal cell nevus syndrome
12) Confidence 0.10 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 1.68 Pain Relevance 0

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