INT1353

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Context Info
Confidence 0.53
First Reported 1976
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 153
Total Number 156
Disease Relevance 15.05
Pain Relevance 75.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
neuronal 14
striatum 13
nerves 8
hippocampus 7
brain 4
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 205 100.00 Very High Very High Very High
Morphine 162 100.00 Very High Very High Very High
tetrodotoxin 120 100.00 Very High Very High Very High
Opioid 117 100.00 Very High Very High Very High
Somatostatin 60 100.00 Very High Very High Very High
gABA 50 100.00 Very High Very High Very High
Nicotine 15 100.00 Very High Very High Very High
narcan 84 99.98 Very High Very High Very High
Enkephalin 76 99.98 Very High Very High Very High
Rostral ventrolateral medulla 31 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Porphyria 8 99.84 Very High Very High Very High
Alzheimer's Dementia 29 99.78 Very High Very High Very High
Ganglion Cysts 17 99.74 Very High Very High Very High
Opiate Addiction 48 99.72 Very High Very High Very High
Multiple System Atrophy 8 99.60 Very High Very High Very High
Infection 6 99.14 Very High Very High Very High
Anxiety Disorder 15 98.76 Very High Very High Very High
Substance Withdrawal Syndrome 4 98.50 Very High Very High Very High
Urological Neuroanatomy 16 98.34 Very High Very High Very High
Shock 5 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Robust FLU-mediated inhibition of ACh release was evident in slices from pCOC male and pCOC diestrus female rats vs. their respective PSAL control groups.
Negative_regulation (inhibition) of Localization (release) of ACh associated with fluoxetine
1) Confidence 0.53 Published 2002 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12502023 Disease Relevance 0 Pain Relevance 0.90
CONCLUSION: The fact that all classic anesthetics reported previously, as well as isoflurane, reduce ACh release supports the hypothesis that the suppression of cholinergic cells is, at least in part one of the mechanisms of anesthesia.


Negative_regulation (reduce) of Localization (release) of ACh
2) Confidence 0.51 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9422302 Disease Relevance 0 Pain Relevance 0
The increased ACh release induced by local application of morphine was reversed by pretreatment with naloxone (1 mg/kg i.p.).
Negative_regulation (reversed) of Localization (release) of ACh associated with narcan and morphine
3) Confidence 0.43 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336550 Disease Relevance 0 Pain Relevance 1.44
Moreover, oxotremorine, but not pilocarpine, inhibited ACh release in a concentration-dependent manner in either basal- or picric acid-evoked conditions, indicating the presence of muscarinic M2-receptors for auto-regulation of ACh release.
Negative_regulation (inhibited) of Localization (release) of ACh
4) Confidence 0.43 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 2875422 Disease Relevance 0 Pain Relevance 0.23
The increased ACh release induced by local application of morphine was attenuated by pretreatment with yohimbine, but not prazosin.
Negative_regulation (attenuated) of Localization (release) of ACh associated with morphine
5) Confidence 0.43 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 14600399 Disease Relevance 0 Pain Relevance 1.07
TTX injected in the caudal ventrolateral medulla (CVLM) inhibited the phenylephrine-induced increase of ACh release.
Negative_regulation (inhibited) of Localization (release) of ACh in medulla associated with medulla and tetrodotoxin
6) Confidence 0.43 Published 1998 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 9533616 Disease Relevance 0.08 Pain Relevance 0.95
These results indicate that T. spiralis infection in the rat is accompanied by a reversible suppression of ACh release from the longitudinal muscle-myenteric plexus of the jejunum.
Negative_regulation (suppression) of Localization (release) of ACh in jejunum associated with infection
7) Confidence 0.43 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2692462 Disease Relevance 0.10 Pain Relevance 0.15
The sevoflurane-induced ACh release was inhibited by 1,2-bis (2-aminophenoxy) ethane-N,N,N',N'-tetra-acetic acid (BAPTA-AM), suggesting the involvement of intracellular calcium-sensitive stores in the process.
Negative_regulation (inhibited) of Localization (release) of ACh
8) Confidence 0.43 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16133935 Disease Relevance 0 Pain Relevance 0.14
The sevoflurane-induced ACh release was not blocked by tetrodotoxin (TTX) and therefore was independent of sodium channels.
Negative_regulation (blocked) of Localization (release) of ACh associated with tetrodotoxin and sodium channel
9) Confidence 0.43 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16133935 Disease Relevance 0 Pain Relevance 0.15
CONCLUSIONS: Our findings showed that as a results of estrogen deficiency, Ach release from nerve fibres decreased, suggesting that this reduction of Ach released from cholinergic nerves may cause the decrease in detrusor contractility.
Negative_regulation (decreased) of Localization (release) of Ach in nerves
10) Confidence 0.43 Published 2007 Journal Neurourol. Urodyn. Section Body Doc Link 17480029 Disease Relevance 0.11 Pain Relevance 0
Inhibition of ACh release by 5-HT appears to be mediated by a complex relationship between 5-HT2, 5-HT3 and D2 receptor regulation, as the blockade of any of these receptors reversed the inhibitory effects of FLU on ACh release.
Negative_regulation (Inhibition) of Localization (release) of ACh associated with fluoxetine
11) Confidence 0.39 Published 2002 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12502023 Disease Relevance 0 Pain Relevance 0.71
Given our previous findings of accentuated inhibition of ACh release by 5-HT3 agonism in striata of pCOC-exposed adult rats, we hypothesized that superfusion of endogenous and exogenous 5-HT would lead to greater suppression of evoked ACh release in this group of animals.
Negative_regulation (inhibition) of Localization (release) of ACh
12) Confidence 0.39 Published 2002 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12502023 Disease Relevance 0 Pain Relevance 0.67
Given our previous findings of accentuated inhibition of ACh release by 5-HT3 agonism in striata of pCOC-exposed adult rats, we hypothesized that superfusion of endogenous and exogenous 5-HT would lead to greater suppression of evoked ACh release in this group of animals.
Negative_regulation (suppression) of Localization (release) of ACh
13) Confidence 0.39 Published 2002 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12502023 Disease Relevance 0 Pain Relevance 0.71
Our results indicated that ACh release from slices of all prenatal saline (pSAL) rats was inhibited comparably by FLU (10 microM)-elicited increases in endogenous 5-HT or by increases elicited with application of exogenous 5-HT (5 microM).
Negative_regulation (inhibited) of Localization (release) of ACh associated with fluoxetine
14) Confidence 0.39 Published 2002 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12502023 Disease Relevance 0 Pain Relevance 0.86
On day 5 of spontaneous abstinence from chronic morphine treatment (10-40 mg/kg morphine dose once daily for 5 days), when withdrawal symptoms were still present, even a lower morphine dose (5 mg/kg) was effective in decreasing ACh release in the NAc.
Negative_regulation (decreasing) of Localization (release) of ACh in NAc associated with nucleus accumbens, withdrawal and morphine
15) Confidence 0.38 Published 1999 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10102787 Disease Relevance 0.19 Pain Relevance 0.98
Acute administration of morphine dose-dependently decreased acetylcholine (ACh) release in the nucleus accumbens (NAc), with 10 mg/kg s.c. being most effective, 5 mg/kg ineffective.
Negative_regulation (decreased) of Localization (release) of ACh in NAc associated with nucleus accumbens and morphine
16) Confidence 0.38 Published 1999 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10102787 Disease Relevance 0.15 Pain Relevance 0.81
Phenobarbital inhibited the K-stimulated [3H]ACh release and the IC50 was equal to that found for K-stimulated endogenous ACh release.
Negative_regulation (inhibited) of Localization (release) of ACh
17) Confidence 0.38 Published 1980 Journal Neurochem. Res. Section Abstract Doc Link 6968410 Disease Relevance 0 Pain Relevance 0.15
The d-norfenfluramine-induced increase in cortical ACh release was tetrodotoxin sensitive and completely prevented by a 7-day chemical degeneration of the serotonergic afferents to the frontal cortex.
Negative_regulation (prevented) of Localization (release) of ACh in frontal cortex associated with tetrodotoxin and urological neuroanatomy
18) Confidence 0.38 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627564 Disease Relevance 0.36 Pain Relevance 0.28
Formalin treatment decreased ACh release only in animals considered 'Inactive' during the Novelty phase while no modification in ACh release was observed in the 'Active' ones.
Negative_regulation (decreased) of Localization (release) of ACh
19) Confidence 0.38 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067465 Disease Relevance 0.30 Pain Relevance 0.23
Optimal stimulation parameters for eliciting ACh release from cholinergic neurons differed from those required for eliciting DA release from dopaminergic terminals: at 0.6 ms pulse duration, 20 Hz and 200 microA, ACh release increased to 357 +/- 30% (P < 0.01) of baseline and was blocked by the addition of tetrodotoxin (TTX).
Negative_regulation (blocked) of Localization (release) of ACh in cholinergic neurons associated with tetrodotoxin and dopamine
20) Confidence 0.38 Published 1993 Journal Brain Res. Section Abstract Doc Link 8481795 Disease Relevance 0 Pain Relevance 0.41

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