INT13530

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Context Info
Confidence 0.17
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.48
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GABRB3) transport (GABRB3) plasma membrane (GABRB3)
transmembrane transport (GABRB3)
Anatomy Link Frequency
neocortex 1
GABRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 4 99.96 Very High Very High Very High
gABA 40 99.44 Very High Very High Very High
nMDA receptor antagonist 2 96.60 Very High Very High Very High
agonist 3 96.04 Very High Very High Very High
antagonist 3 94.68 High High
Cannabinoid receptor 14 91.20 High High
nMDA receptor 1 90.16 High High
Action potential 5 89.40 High High
Serotonin 2 88.96 High High
GABA receptor 4 85.12 High High
Disease Link Frequency Relevance Heat
Myoclonus 17 99.92 Very High Very High Very High
Convulsion 5 98.16 Very High Very High Very High
Lifespan 27 89.92 High High
Epilepsy 4 76.28 Quite High
Cerebral Hypoxia 1 56.84 Quite High
Aging 17 44.40 Quite Low
Disease 1 43.64 Quite Low
Shock 1 33.80 Quite Low
Amblyopia 7 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that reduction or blockade of the GABAA receptor is sufficient to elicit epileptiform discharges in the human neocortex maintained in vitro.
Negative_regulation (reduction) of GABAA receptor in neocortex
1) Confidence 0.17 Published 1991 Journal Exp Brain Res Section Abstract Doc Link 1673658 Disease Relevance 0 Pain Relevance 0.20
Blockade of GABAA receptors or GABA synthesis regularly evokes convulsive seizures, but administration of many GABA agonists and some GABA uptake blockers paradoxically may evoke myoclonus.
Negative_regulation (Blockade) of GABAA associated with myoclonus, gaba, convulsion and agonist
2) Confidence 0.17 Published 1990 Journal FASEB J. Section Abstract Doc Link 2165012 Disease Relevance 1.39 Pain Relevance 0.55
3), a monotonic increase or decrease (GABAA?
Negative_regulation (decrease) of GABAA
3) Confidence 0.10 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.09 Pain Relevance 0.36
In agreement with the finding that ISOs are resistant to ionotropic glutamate, GABAA and GABAB receptor blockers, the ISO-related long-lasting hyperpolarizing potentials were resistant to the combined application of the GABAA and GABAB receptor antagonists, SR95531 (10 µM) and CGP54626 (10 µM), respectively (n?
Negative_regulation (blockers) of GABAA associated with glutamate and antagonist
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637539 Disease Relevance 0 Pain Relevance 0.20

General Comments

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