INT135306

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 4.37
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C8) endoplasmic reticulum (CYP2C8)
Anatomy Link Frequency
heart 1
CYP2C8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 98.24 Very High Very High Very High
Morphine 1 29.60 Quite Low
Inflammation 24 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 15 99.88 Very High Very High Very High
Hypothermia 242 99.80 Very High Very High Very High
Adverse Drug Reaction 1 99.04 Very High Very High Very High
Hypertension 14 99.00 Very High Very High Very High
INFLAMMATION 30 97.52 Very High Very High Very High
Disease 18 97.52 Very High Very High Very High
Reprotox - General 1 46 97.48 Very High Very High Very High
Stroke 13 96.08 Very High Very High Very High
Hemorrhage 2 95.52 Very High Very High Very High
Myocardial Infarction 44 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding.
CYP2C8 Binding (Interaction) of associated with inflammation, cinod and hemorrhage
1) Confidence 0.46 Published 2008 Journal Pharmacogenet. Genomics Section Title Doc Link 18216720 Disease Relevance 0.19 Pain Relevance 0.28
Linkage disequilibrium between CYP2C9 and CYP2C8
CYP2C8 Binding (Linkage) of
2) Confidence 0.37 Published 2009 Journal Pharmacogenomics J Section Body Doc Link PMC2782405 Disease Relevance 0.18 Pain Relevance 0
This strong association implies that if any of the three relevant SNPs gives a positive result in a caseĀ–control study, it will be difficult to distinguish any association with CYP2C9 from an association with CYP2C8 and vice versa.
CYP2C8 Binding (association) of
3) Confidence 0.37 Published 2009 Journal Pharmacogenomics J Section Body Doc Link PMC2782405 Disease Relevance 0.08 Pain Relevance 0
[Clinical pharmacogenomics for CYP2C8 and CYP2C9: general concepts and application to the use of NSAIDs].
CYP2C8 Binding (pharmacogenomics) of associated with cinod
4) Confidence 0.37 Published 2006 Journal Farm Hosp Section Title Doc Link 17022718 Disease Relevance 0 Pain Relevance 0.19
In addition, the observed intraethnic variability reinforces the need for proper selection of control subjects and points against the use of surrogate control groups for studies involving association of CYP2C8 or CYP2C9 alleles with adverse drug reactions or spontaneous diseases.
CYP2C8 Binding (association) of associated with adverse drug reaction and disease
5) Confidence 0.37 Published 2006 Journal Molecular diagnosis & therapy Section Abstract Doc Link 16646575 Disease Relevance 0.20 Pain Relevance 0
A study in African Americans also found no association between the epoxygenase gene SNPs (CYP2C8, 2C9, 2J2, and sEH) and hypertension [33].
CYP2C8 Neg (no) Binding (association) of associated with hypertension
6) Confidence 0.36 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 1.08 Pain Relevance 0
Though our retrospective investigation did not find the same association between the CYP2C8 rs1934951 SNP and the development ONJ as Sarasquete et al,25 more studies in independent patient cohorts are necessary to determine if genetic polymorphisms in CYP2C8 are a risk factor for the development of ONJ.
CYP2C8 Neg (not) Binding (association) of
7) Confidence 0.36 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999510 Disease Relevance 0.26 Pain Relevance 0
There are several possible reasons why our study did not find an association between the CYP2C8 SNP and development of ONJ.
CYP2C8 Neg (not) Binding (association) of
8) Confidence 0.36 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999510 Disease Relevance 0.27 Pain Relevance 0
We emphasized SNPs at CYP2C8 but, based on some reports of LD with CYP2C9,6, 23 we included two SNPs at the 5?
CYP2C8 Binding (emphasized) of
9) Confidence 0.32 Published 2009 Journal Pharmacogenomics J Section Body Doc Link PMC2782405 Disease Relevance 0 Pain Relevance 0
Comprehensive assessment of the drug interaction between gemfibrozil and cytochrome P450 2C8 substrates requires a clear understanding of gemfibrozil glucuronidation.
cytochrome P450 2C8 Spec (clear) Binding (interaction) of
10) Confidence 0.29 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17670842 Disease Relevance 0 Pain Relevance 0
Interaction of CPC, NSE and hypothermia
CPC Binding (Interaction) of associated with hypothermia
11) Confidence 0.02 Published 2010 Journal Crit Care Section Body Doc Link PMC2887191 Disease Relevance 1.08 Pain Relevance 0
The association of neurological outcome (CPC 1 to 2 vs. 3 to 5), NSE serum levels and MTH was adjusted for confounders using a logistic regression model including gender, age, APACHE II-score, epinephrine dosage, bystander CPR, time to ROSC, location of cardiac arrest and initial heart rhythm as independent variables.
CPC Binding (association) of in heart associated with hypothermia and myocardial infarction
12) Confidence 0.02 Published 2010 Journal Crit Care Section Body Doc Link PMC2887191 Disease Relevance 1.04 Pain Relevance 0

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