INT135313

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.44
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
medial 1
amygdala 1
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 8 100.00 Very High Very High Very High
amygdala 3 100.00 Very High Very High Very High
antidepressant 43 98.72 Very High Very High Very High
Hippocampus 5 97.84 Very High Very High Very High
depression 79 96.80 Very High Very High Very High
Desipramine 2 91.76 High High
fluoxetine 5 89.60 High High
Lasting pain 20 89.20 High High
Neuropathic pain 5 85.56 High High
Limbic system 4 85.12 High High
Disease Link Frequency Relevance Heat
Injury 8 100.00 Very High Very High Very High
Depression 96 96.80 Very High Very High Very High
Multiple Sclerosis 132 95.56 Very High Very High Very High
Stress 89 92.08 High High
Nociception 3 91.68 High High
Pain 43 89.20 High High
Neuropathic Pain 5 85.56 High High
Traumatic Stress Disorders 1 67.72 Quite High
Anxiety Disorder 23 67.52 Quite High
Disease 30 66.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, glucocorticoid receptor mRNA expression in CCI rats was increased in the medial and central amygdala, unaffected in the paraventricular nucleus, and decreased in the hippocampus.
Neg (unaffected) Regulation (unaffected) of in amygdala Gene_expression (expression) of glucocorticoid receptor mRNA in medial associated with eae, hippocampus and amygdala
1) Confidence 0.39 Published 2006 Journal Physiol. Behav. Section Abstract Doc Link 16647726 Disease Relevance 1.71 Pain Relevance 1.32
Analysis of another indicator of HPA axis activity and regulation, glucocorticoid receptor (GR) expression, showed an increase in all groups of animals compared with their controls, 21 days after the onset of experiment (figure 1D; F: 14,74, dF: 7), indicating a normal regulation of the HPA axis.


Regulation (regulation) of Gene_expression (expression) of glucocorticoid receptor
2) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.21 Pain Relevance 0.07
Antidepressant drugs have been suggested to exert their clinical action via a facilitation of glucocorticoid receptor gene expression and function in the HPA (Brady et al 1991).
Regulation (facilitation) of Gene_expression (expression) of glucocorticoid receptor associated with antidepressant
3) Confidence 0.03 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654524 Disease Relevance 0.52 Pain Relevance 0.55

General Comments

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