INT135319

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 26.45
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
plasma 10
white blood cell 4
upper 2
neutrophils 2
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 354 100.00 Very High Very High Very High
Adalimumab 207 100.00 Very High Very High Very High
Inflammatory marker 50 100.00 Very High Very High Very High
imagery 20 100.00 Very High Very High Very High
anesthesia 6 100.00 Very High Very High Very High
Pain 45 98.04 Very High Very High Very High
cytokine 160 97.64 Very High Very High Very High
rheumatoid arthritis 52 97.16 Very High Very High Very High
headache 9 95.84 Very High Very High Very High
Inflammatory response 38 88.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 461 100.00 Very High Very High Very High
Disease 194 100.00 Very High Very High Very High
Cancer 155 100.00 Very High Very High Very High
Colon Cancer 93 100.00 Very High Very High Very High
Fever 30 100.00 Very High Very High Very High
Coagulation Disorder 10 100.00 Very High Very High Very High
Leukocytosis 4 99.96 Very High Very High Very High
Metabolic Disorder 2 99.90 Very High Very High Very High
Alzheimer's Dementia 42 99.64 Very High Very High Very High
Metabolic Syndrome 9 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is still unclear whether CRP levels are elevated before the biological onset of cancer or if an elevated CRP level is also a risk factor for the development of cancer.
Spec (whether) Positive_regulation (elevated) of Spec (whether) Positive_regulation (elevated) of CRP associated with cancer
1) Confidence 0.50 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2921363 Disease Relevance 1.60 Pain Relevance 0.37
In addition, several inflammation markers, such as erythrocyte sedimentation rate (ESR), white blood cell count (WBC), fibrinogen and high sensitive C-reactive protein (hs-CRP) were all elevated.
Positive_regulation (elevated) of Positive_regulation (elevated) of C-reactive protein in white blood cell associated with inflammation
2) Confidence 0.47 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 2.31 Pain Relevance 0.22
A raised baseline CRP value has been associated with inflammation, endothelial dysfunction, obesity [17], the metabolic syndrome [18, 19], diabetes mellitus [20], insulin resistance [7], and severity of hypertension [21], and thus, various metabolic disorders may occur by increasing CRP level and simultaneously promote an increase in LV mass.
Positive_regulation (occur) of Positive_regulation (increasing) of CRP associated with metabolic disorder, inflammation, diabetes mellitus, hypertension, obesity, metabolic syndrome and insulin resistance
3) Confidence 0.46 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975076 Disease Relevance 1.39 Pain Relevance 0.12
A nested case-control study showed that individuals with CRP concentrations in the highest quartile had a significantly higher risk for the incidence of colon cancer compared with individuals in the lowest quartile.13 In contrast, another prospective study demonstrated that an elevated plasma CRP level was not a predictor of colorectal cancer but was merely increased after the onset of colorectal cancer.14
Neg (not) Positive_regulation (increased) of Positive_regulation (elevated) of CRP in plasma associated with colon cancer
4) Confidence 0.44 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687750 Disease Relevance 1.95 Pain Relevance 0.45
The serum levels of PCT and CRP were measured before the induction of anesthesia, in the fourth and eighth hours after graft reperfusion, and continued daily to the fourth day after surgery.
Positive_regulation (measured) of Positive_regulation (levels) of CRP associated with anesthesia
5) Confidence 0.41 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.12 Pain Relevance 0.17
The serum levels of PCT and CRP were measured before the induction of anesthesia, in the fourth and eighth hours after graft reperfusion, and continued daily to the fourth day after surgery.
Positive_regulation (continued) of Positive_regulation (levels) of CRP associated with anesthesia
6) Confidence 0.41 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.14 Pain Relevance 0.18
In addition, several inflammation markers, such as erythrocyte sedimentation rate (ESR), white blood cell count (WBC), fibrinogen and high sensitive C-reactive protein (hs-CRP) were all elevated.
Positive_regulation (elevated) of Positive_regulation (sensitive) of hs-CRP in white blood cell associated with inflammation
7) Confidence 0.41 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 2.31 Pain Relevance 0.22
It has also been observed that patients with elevated CRP or greater amounts of inflammation on MRI may respond better to TNF inhibitors (Maksymowych et al. 2006; van der Heijde et al. 2006b).
Spec (may) Positive_regulation (respond) of Positive_regulation (elevated) of CRP associated with inflammation and imagery
8) Confidence 0.39 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012440 Disease Relevance 0.77 Pain Relevance 0.92
Laboratory tests showed a hemoglobin level of 10.3 g/dL, a leukocyte level of 6,900/mm(3), with an increased proportion of segmented nuclear neutrophils (83%), and an elevated C-reactive protein.
Positive_regulation (showed) of Positive_regulation (elevated) of C-reactive protein in neutrophils
9) Confidence 0.35 Published 2006 Journal Int. J. Dermatol. Section Abstract Doc Link 16650178 Disease Relevance 0.98 Pain Relevance 0.10
After both laparoscopic and open colorectal surgery, we observed a significant increase of circulating CRP levels and this increase was similar between the two groups on POD 1 and POD 4.
Positive_regulation (increase) of Positive_regulation (increase) of CRP
10) Confidence 0.34 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2988071 Disease Relevance 0.64 Pain Relevance 0
It has been shown that patients with a primary PCI treated STEMI generate a marked, short-term increase in circulating levels of inflammatory markers [18] and higher levels of CRP and IL-6 in patients with acute myocardial infarction and diabetes compared to patients without diabetes have also been reported [19].
Positive_regulation (increase) of Positive_regulation (levels) of CRP associated with diabetes mellitus, inflammatory marker and myocardial infarction
11) Confidence 0.24 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 1.02 Pain Relevance 0.31
Prior to the start of the therapy, increased levels of CRP were detected in six patients.
Positive_regulation (increased) of Positive_regulation (levels) of CRP
12) Confidence 0.23 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3004381 Disease Relevance 0.06 Pain Relevance 0
Prior to the start of the therapy, increased levels of CRP were detected in six patients.
Positive_regulation (levels) of Positive_regulation (increased) of CRP
13) Confidence 0.23 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3004381 Disease Relevance 0.06 Pain Relevance 0
Inflammation is recognized as a major etiologic determinant of multiple disease states including myocardial infarction, stroke, diabetes, and metabolic syndrome, and individuals with elevated levels of the inflammatory biomarkers such as CRP are at increased risk of mortality and morbidity from these conditions[8].
Positive_regulation (increased) of Positive_regulation (elevated) of CRP associated with inflammation, diabetes mellitus, stroke, metabolic syndrome, disease and myocardial infarction
14) Confidence 0.17 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2588593 Disease Relevance 1.59 Pain Relevance 0.22
A transient elevation of CRP occurred in both volunteers: a CRP level of 75 mg/L (upper limit of normal is < 8 mg/L) was seen in the volunteer with the severe reaction while the other volunteer had only a mild elevation of CRP with a value of 8 mg/L.
Positive_regulation (occurred) of Positive_regulation (elevation) of CRP in upper
15) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440546 Disease Relevance 0.85 Pain Relevance 0.28
A local reaction at the site of injury or infection leads to an activation of cytokines (specifically, IL-6, IL-1, TNF-Alpha, and interferons) that triggers a systemic response consisting of leukocytosis; increases in glucocorticoid production; increases in erythrocyte sedimentation rates, fever, activation of complement and clotting cascades; decreases in serum zinc and iron; and an increase in plasma levels of acute phase proteins, C-reactive protein (CRP), serum amyloid A, fibrinogen, and other proteins [12].
Positive_regulation (increases) of Positive_regulation (increase) of CRP in plasma associated with coagulation disorder, alzheimer's dementia, leukocytosis, injury, fever, infection and cytokine
16) Confidence 0.15 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 2.34 Pain Relevance 0.39
A local reaction at the site of injury or infection leads to an activation of cytokines (specifically, IL-6, IL-1, TNF-Alpha, and interferons) that triggers a systemic response consisting of leukocytosis; increases in glucocorticoid production; increases in erythrocyte sedimentation rates, fever, activation of complement and clotting cascades; decreases in serum zinc and iron; and an increase in plasma levels of acute phase proteins, C-reactive protein (CRP), serum amyloid A, fibrinogen, and other proteins [12].
Positive_regulation (increases) of Positive_regulation (increase) of C-reactive protein in plasma associated with coagulation disorder, alzheimer's dementia, leukocytosis, injury, fever, infection and cytokine
17) Confidence 0.15 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 2.26 Pain Relevance 0.39
A local reaction at the site of injury or infection leads to an activation of cytokines (specifically, IL-6, IL-1, TNF-Alpha, and interferons) that triggers a systemic response consisting of leukocytosis; increases in glucocorticoid production; increases in erythrocyte sedimentation rates, fever, activation of complement and clotting cascades; decreases in serum zinc and iron; and an increase in plasma levels of acute phase proteins, C-reactive protein (CRP), serum amyloid A, fibrinogen, and other proteins [12].
Positive_regulation (increases) of Positive_regulation (increase) of CRP in plasma associated with coagulation disorder, alzheimer's dementia, leukocytosis, injury, fever, infection and cytokine
18) Confidence 0.15 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 2.26 Pain Relevance 0.39
A local reaction at the site of injury or infection leads to an activation of cytokines (specifically, IL-6, IL-1, TNF-Alpha, and interferons) that triggers a systemic response consisting of leukocytosis; increases in glucocorticoid production; increases in erythrocyte sedimentation rates, fever, activation of complement and clotting cascades; decreases in serum zinc and iron; and an increase in plasma levels of acute phase proteins, C-reactive protein (CRP), serum amyloid A, fibrinogen, and other proteins [12].
Positive_regulation (increases) of Positive_regulation (increase) of C-reactive protein in plasma associated with coagulation disorder, alzheimer's dementia, leukocytosis, injury, fever, infection and cytokine
19) Confidence 0.15 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 2.34 Pain Relevance 0.39
Baseline disease characteristics were consistent with what is generally observed in patients with RA with moderate to severe disease and were comparable between treatment groups with the following exceptions: the mean of the patient’s global assessment of disease activity for the placebo group (64.6 mm) was lower than those for the adalimumab groups (20 mg: 73.1 mm; 40 mg: 71.2 mm; 80 mg: 75.7 mm; P = 0.003); the mean of HAQ DI for the placebo group (1.39) was lower than those for the adalimumab groups (20 mg: 1.57; 40 mg: 1.64; 80 mg: 1.77; P = 0.010); and the mean CRP for the 20 mg group (4.97 mg/dl) was lower than those for other groups (placebo: 5.86 mg/dl; 40 mg: 6.48 mg/dl; 80 mg: 6.56 mg/dl; P = 0.020).


Positive_regulation (assessment) of Positive_regulation (mean) of CRP associated with rheumatoid arthritis, adalimumab and disease
20) Confidence 0.08 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2668560 Disease Relevance 0.68 Pain Relevance 0.44

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