INT135337

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Context Info
Confidence 0.72
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PTPRN2)
Anatomy Link Frequency
facet 1
brain 1
PTPRN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 2 94.04 High High
Hypertelorism 2 93.72 High High
Microcephaly 8 92.24 High High
Congenital Anomalies 22 85.64 High High
Birth Weight 3 80.40 Quite High
Neurodegenerative Disease 2 62.28 Quite High
Ceroid Lipofuscinosis 1 60.00 Quite High
Disease 1 47.28 Quite Low
Intellectual Impairment 6 45.60 Quite Low
Conduct Disorder 1 36.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTPRN2 (protein tyrosine phosphatase, receptor type N), NCAPG2 (leucine zipper protein 5), VIPR2 (vasoactive intestinal peptide receptor 2), FAM62B (family with sequence similarity 62) and WDR60 (WD repeat domain 60) are expressed in human brain.
Gene_expression (expressed) of PTPRN2 in brain
1) Confidence 0.72 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.82 Pain Relevance 0
STUDY DESIGN: A human cadaveric biomechanical study in which the facet forces and instant axes of rotation (IAR) were measured for different spinal positions under simulated weightbearing conditions before and after total disc replacement at L5/S1 using semiconstrained (3 degrees of freedom [DOF]; Prodisc) and unconstrained (5 DOF; Charité) articulated implants.
Gene_expression (measured) of IAR in facet
2) Confidence 0.66 Published 2006 Journal Spine J Section Body Doc Link 16651219 Disease Relevance 0 Pain Relevance 0

General Comments

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