INT135355

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.83
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
brain 1
dorsal horn 1
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 2 99.92 Very High Very High Very High
Dorsal horn 66 97.68 Very High Very High Very High
fluoxetine 12 96.12 Very High Very High Very High
cocaine 6 95.56 Very High Very High Very High
addiction 2 84.04 Quite High
IPN 10 79.16 Quite High
medulla 6 77.88 Quite High
Nortriptyline 3 76.88 Quite High
Hippocampus 7 73.96 Quite High
long-term potentiation 2 72.12 Quite High
Disease Link Frequency Relevance Heat
Retts Disease 5 96.44 Very High Very High Very High
Inflammatory Pain 10 79.16 Quite High
Pain 32 70.76 Quite High
Nociception 4 67.72 Quite High
INFLAMMATION 30 63.12 Quite High
Arthritis 6 62.96 Quite High
Urological Neuroanatomy 3 31.20 Quite Low
Nervous System Injury 2 26.72 Quite Low
Targeted Disruption 2 22.08 Low Low
Repression 4 15.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using immunohistochemistry, we found that Mecp2, as well as the methyl-CpG-binding protein MBD1, were significantly induced in normal adult rat brain after repeated injections of fluoxetine or cocaine for 10 days (one injection per day).
Mecp2 Binding (methyl-CpG-binding) of in brain associated with cocaine and fluoxetine
1) Confidence 0.37 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16670375 Disease Relevance 0.10 Pain Relevance 0.35
However, it is well accepted that MeCP2 activity is extremely cell type specific and therefore we cannot exclude a possible direct interaction between MeCP2 and Fos or/and Zif268 promoter region within superficial dorsal horn neurones.
MeCP2 Neg (cannot) Binding (interaction) of in dorsal horn associated with dorsal horn
2) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.26 Pain Relevance 0.44
Once bound to methylated CpG sites, methyl-CpG-binding protein 2 (MeCP2) is thought to silence transcription of downstream genes by recruiting a histone deacetylase (HDAC).
MeCP2 Binding (bound) of
3) Confidence 0.36 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16670375 Disease Relevance 0.09 Pain Relevance 0.24
Once bound to methylated CpG sites, methyl-CpG-binding protein 2 (MeCP2) is thought to silence transcription of downstream genes by recruiting a histone deacetylase (HDAC).
methyl-CpG-binding protein 2 Binding (bound) of
4) Confidence 0.36 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16670375 Disease Relevance 0.09 Pain Relevance 0.24
MeCP2 regulates gene transcription by binding to methylated CpG dinucleotides and recruiting co-repressors such as histone deacetylases to promote chromatin compaction and reduce access of transcription factors to promoter DNA [5].
MeCP2 Binding (binding) of
5) Confidence 0.35 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.30 Pain Relevance 0.45

General Comments

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