INT135359

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 14
Disease Relevance 4.35
Pain Relevance 6.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
lamina 4
brain 3
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 6 99.98 Very High Very High Very High
fluoxetine 12 99.74 Very High Very High Very High
Serotonin 75 99.46 Very High Very High Very High
Dorsal horn 363 98.96 Very High Very High Very High
Thermal hyperalgesia 33 97.40 Very High Very High Very High
central sensitization 66 96.48 Very High Very High Very High
Pain 176 96.28 Very High Very High Very High
Inflammation 187 95.72 Very High Very High Very High
Nortriptyline 3 95.52 Very High Very High Very High
intrathecal 77 94.84 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 33 97.40 Very High Very High Very High
Retts Disease 14 96.44 Very High Very High Very High
Pain 176 96.28 Very High Very High Very High
INFLAMMATION 165 95.72 Very High Very High Very High
Repression 22 93.76 High High
Neuropathic Pain 11 91.88 High High
Targeted Disruption 11 88.20 High High
Inflammatory Pain 55 87.12 High High
Injury 22 85.08 High High
Arthritis 33 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mecp2 was not induced by repeated injections of 1-(2-bis(4-fluorphenyl)-methoxy)-ethyl)-4-(3-phenyl-propyl)piperazine (GBR-12909) or nortriptyline.
Positive_regulation (induced) of Mecp2 associated with nortriptyline
1) Confidence 0.70 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16670375 Disease Relevance 0.09 Pain Relevance 0.44
Using immunohistochemistry, we found that Mecp2, as well as the methyl-CpG-binding protein MBD1, were significantly induced in normal adult rat brain after repeated injections of fluoxetine or cocaine for 10 days (one injection per day).
Positive_regulation (induced) of Mecp2 in brain associated with cocaine and fluoxetine
2) Confidence 0.70 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16670375 Disease Relevance 0.10 Pain Relevance 0.36
Fluoxetine and cocaine induce the epigenetic factors MeCP2 and MBD1 in adult rat brain.
Positive_regulation (induce) of MeCP2 in brain associated with cocaine and fluoxetine
3) Confidence 0.70 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16670375 Disease Relevance 0.09 Pain Relevance 0.45
Evidence also suggests that an increase in P-MeCP2 may lead to a persistent up-regulation of Fos as seen here at 6 h and 24 h following CFA.
Positive_regulation (increase) of P-MeCP2
4) Confidence 0.59 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.25 Pain Relevance 0.41
First, we report that CFA significantly increased P-MeCP2 in Lamina I and II, from 30 min post injection, with a maximum reached after 1 h.
Positive_regulation (increased) of P-MeCP2 in Lamina
5) Confidence 0.46 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2553762 Disease Relevance 0.53 Pain Relevance 0.55
Crucially, P-MeCP2, Zif268 and Fos are all up-regulated in lamina I, NK1 positive, projection neurones following peripheral noxious stimulation: after peripheral inflammation 47% and 27% of projection neurones expressed Zif268 [30] and P-MeCP2 [7] respectively.
Positive_regulation (regulated) of P-MeCP2 in lamina associated with inflammation
6) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.30 Pain Relevance 0.41
We show that the activation or expression of the transcription factors MeCP2, Zif268 and Fos after primary afferents stimulation depend on convergent input from primary afferents and descending pathways from the brain.
Positive_regulation (activation) of MeCP2 in brain
7) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.28 Pain Relevance 0.33
We have therefore investigated the contribution of serotonergic inputs to the activation of transcription factors MeCP2, Zif268 and Fos as well as on the development of mechanical and thermal hyperalgesia induced by peripheral inflammation.
Positive_regulation (activation) of MeCP2 associated with inflammation and thermal hyperalgesia
8) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.75 Pain Relevance 0.75
Crucially, P-MeCP2, Zif268 and Fos are all up-regulated in lamina I, NK1 positive, projection neurones following peripheral noxious stimulation: after peripheral inflammation 47% and 27% of projection neurones expressed Zif268 [30] and P-MeCP2 [7] respectively.
Positive_regulation (up) of P-MeCP2 in lamina associated with inflammation
9) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.30 Pain Relevance 0.41
Crucially, P-MeCP2, Zif268 and Fos are all up-regulated in lamina I, NK1 positive, projection neurones following peripheral noxious stimulation: after peripheral inflammation 47% and 27% of projection neurones expressed Zif268 [30] and P-MeCP2 [7] respectively.
Positive_regulation (-) of P-MeCP2 in lamina associated with inflammation
10) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.30 Pain Relevance 0.41
There was a significant increase in P-MeCP2, Zif268 and Fos from 30 min post CFA.
Positive_regulation (increase) of P-MeCP2
11) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.09
In the present study, we were able to show that serotonin depletion attenuated both MeCP2 activation and the increased mechanical sensitivity that follows CFA injection, again strengthening the correlation between transcription factors activation and changes in behaviour.
Positive_regulation (activation) of MeCP2 associated with serotonin
12) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.84 Pain Relevance 0.79
Although the levels of P-MeCP2 and Zif268 seen 6 h after CFA were no different from that in naïve animals, there was a significant upregulation in the levels of P-MeCP2, Zif268 and Fos 24 h after CFA (increase to 21 ± 3 immunopositive nuclei (P < 0.01), 31 ± 8 immunopositive nuclei (P < 0.05) and 32 ± 1 (P < 0.01) respectively).


Positive_regulation (upregulation) of P-MeCP2
13) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.10
The increase in P-MeCP2 paralleled that of Zif268 and Fos, and P-MeCP2 was expressed in large sub-populations of Zif268 and Fos expressing neurones.
Positive_regulation (increase) of P-MeCP2
14) Confidence 0.40 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2553762 Disease Relevance 0.53 Pain Relevance 0.55

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