INT135366

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.82
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SFRP1) extracellular space (SFRP1) extracellular region (SFRP1)
proteinaceous extracellular matrix (SFRP1) plasma membrane (SFRP1) intracellular (SFRP1)
Anatomy Link Frequency
midbrain 1
SFRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 83 99.64 Very High Very High Very High
midbrain 20 96.88 Very High Very High Very High
Chronic pancreatitis 2 76.52 Quite High
Substantia nigra 1 16.40 Low Low
Action potential 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 7 100.00 Very High Very High Very High
Pancreatic Cancer 10 98.28 Very High Very High Very High
Neurodegenerative Disease 7 93.92 High High
Cancer 26 91.20 High High
Breast Cancer 28 62.44 Quite High
Disease 3 32.00 Quite Low
Adenocarcinoma 1 6.08 Low Low
Hyperplasia 1 5.32 Low Low
Infection 6 5.00 Very Low Very Low Very Low
Pancreatitis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aberrant methylation of secreted apoptosis-related protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms.
Localization (secreted) of SARP2 associated with pancreatic cancer and apoptosis
1) Confidence 0.75 Published 2006 Journal Pancreas Section Title Doc Link 16670620 Disease Relevance 0.72 Pain Relevance 0.08
Aberrant methylation of secreted apoptosis-related protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms.
Localization (secreted) of secreted apoptosis-related protein associated with pancreatic cancer and apoptosis
2) Confidence 0.66 Published 2006 Journal Pancreas Section Title Doc Link 16670620 Disease Relevance 0.71 Pain Relevance 0.08
Methylation and subsequent downregulation of expression of the Wnt-inhibitory gene SFRP1 has previously been observed in all three ?
Localization (observed) of SFRP1
3) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.23 Pain Relevance 0
It should also be noted that we detected significantly higher levels of the soluble Wnt inhibitor secreted Frizzled-related protein 1(sFRP-1) in PA6-DA cells, which is suggested to have an inhibitory effect on ventral midbrain neuronal development (Z-ratio>14) than sFRP-2, which promotes DA neurogenesis and maturation (Z-ratio>3) [71].
Localization (secreted) of sFRP-1 in midbrain associated with dopamine, midbrain and neurodegenerative disease
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.16 Pain Relevance 0.32

General Comments

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