INT135372

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 72
Total Number 82
Disease Relevance 50.03
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
brain 5
neuronal 3
skeletal muscle 2
PC-3 2
dopaminergic neurons 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 374 100.00 Very High Very High Very High
Kinase C 115 99.76 Very High Very High Very High
fluoxetine 14 99.66 Very High Very High Very High
nMDA receptor 15 99.60 Very High Very High Very High
Hippocampus 325 99.48 Very High Very High Very High
antidepressant 39 99.16 Very High Very High Very High
corticosteroid 107 98.92 Very High Very High Very High
long-term potentiation 51 98.84 Very High Very High Very High
Nerve growth factor 6 98.78 Very High Very High Very High
monoamine 50 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 413 100.00 Very High Very High Very High
Toxicity 217 99.96 Very High Very High Very High
Prostate Cancer 28 99.86 Very High Very High Very High
Disease 2243 99.84 Very High Very High Very High
Targeted Disruption 1373 99.84 Very High Very High Very High
Parkinson's Disease 654 99.78 Very High Very High Very High
Diabetes Mellitus 160 99.78 Very High Very High Very High
Stress 336 99.76 Very High Very High Very High
Death 634 99.74 Very High Very High Very High
Cancer 178 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, combination treatment of mice with risperidone and a monoamine reuptake inhibitor antidepressant imipramine or fluoxetine elicited larger increases in brain phospho-Ser-GSK3 than each agent alone.
Positive_regulation (increases) of GSK3 in brain associated with antidepressant, fluoxetine and monoamine
1) Confidence 0.70 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16672106 Disease Relevance 0.34 Pain Relevance 0.35
Our unpublished data also shows glycogen accumulation and GSKser9 (inactive form) elevations in AD brain; most noticeably, we have observed upregulation in the hippocampus, while others have found increased GSK3ser9 in the temporal cortex of AD brain [111].
Positive_regulation (increased) of GSK3 in brain associated with hippocampus and disease
2) Confidence 0.49 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.48 Pain Relevance 0.05
, that is, GSK3ser9 (the inactive form), is actually elevated in astrocytes in AD brain where it correlates with glycogen accumulation, an index of metabolic deficits (Frautschy and Hu, unpublished observations).
Positive_regulation (elevated) of GSK3 in brain associated with disease
3) Confidence 0.49 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.54 Pain Relevance 0
The A1.4 and A1.6 clones initially identified as having a sub-maximal, but significant level of knockdown still retained the same degree of reduction, with A1.6 displaying a higher level of GSK3?
Positive_regulation (level) of GSK3
4) Confidence 0.47 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.08 Pain Relevance 0
(-/-) MEFs using cre-recombinase approaches have been unsuccessful to date, a GSK3?
Positive_regulation (unsuccessful) of GSK3
5) Confidence 0.47 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.32 Pain Relevance 0
The results showed that acute treatment of mice with risperidone rapidly increased the level of brain phospho-Ser-GSK3 in the cortex, hippocampus, striatum, and cerebellum in a dose-dependent manner.
Positive_regulation (increased) of GSK3 in cortex associated with hippocampus
6) Confidence 0.47 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16672106 Disease Relevance 0.43 Pain Relevance 0.31
A potential role for GSK-3?
Positive_regulation (role) of GSK-3
7) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.98 Pain Relevance 0.44
It is possible that inactivation of GSK-3?
Spec (possible) Positive_regulation (inactivation) of GSK-3
8) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.41 Pain Relevance 0.30
It is possible that different neuronal circuits are affected by inactivation of GSK-3?
Positive_regulation (inactivation) of GSK-3 in neuronal
9) Confidence 0.45 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.45 Pain Relevance 0.09
Immortalized fibroblasts that escaped crisis were transduced with a retrovirus expressing self-excising cre recombinase to generate the GSK3?
Positive_regulation (generate) of GSK3 in fibroblasts
10) Confidence 0.44 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.27 Pain Relevance 0
Activation of GSK-3 inhibits the development of long-term potentiation (LTP) [27], whereas its inhibition prevents the development of long-term depression (LTD), as shown in brain slice studies [24-26].
Positive_regulation (Activation) of GSK-3 in brain associated with depression and long-term potentiation
11) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.76 Pain Relevance 0.50
Increased emotionality in GSK-3?
Positive_regulation (Increased) of GSK-3
12) Confidence 0.42 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.34 Pain Relevance 0
OKB, KM, BWD performed GSK-3?
Positive_regulation (performed) of GSK-3
13) Confidence 0.40 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.28 Pain Relevance 0.08
To elucidate the involvement of the cerebellum in morphological changes in GSK-3?
Positive_regulation (changes) of GSK-3 in cerebellum
14) Confidence 0.40 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.17 Pain Relevance 0.11
Inactivation of GSK-3 increases ?
Positive_regulation (increases) of GSK-3
15) Confidence 0.39 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0 Pain Relevance 0.06
As shown in Figures 1A–D, PE stress did indeed activate Akt (and downstream GSK3- ?)
Positive_regulation (activate) of GSK3 associated with stress
16) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.37 Pain Relevance 0
Furthermore, both glucose tolerance and insulin sensitivity showed no significant differences in 8 week (or 6 month (data not shown)) old male MLC Cre + and MLC Cre - littermate control mice (Figures 1D and 1E, respectively) demonstrating that the muscle-specific inactivation of GSK-3?
Positive_regulation (inactivation) of GSK-3 in muscle associated with tolerance and impaired glucose tolerance
17) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.35 Pain Relevance 0.14
Unlike the ICR strain, we observed that global inactivation of GSK-3?
Positive_regulation (inactivation) of GSK-3 associated with sprains and strains
18) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.20 Pain Relevance 0.08
We previously reported that mice that lack GSK-3?
Positive_regulation (lack) of GSK-3
19) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.48 Pain Relevance 0.10
We speculate that the beneficial effect of GSK-3?
Positive_regulation (effect) of GSK-3
20) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.52 Pain Relevance 0.07

General Comments

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