INT135374

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 46
Total Number 47
Disease Relevance 24.36
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
liver 2
neuronal 2
hepatocyte 1
cleavage 1
brain 1
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 48 99.14 Very High Very High Very High
depression 107 98.74 Very High Very High Very High
antidepressant 122 98.68 Very High Very High Very High
Neuritis 4 97.72 Very High Very High Very High
Eae 248 97.24 Very High Very High Very High
tolerance 217 96.48 Very High Very High Very High
corticosteroid 120 95.96 Very High Very High Very High
Hippocampus 88 89.76 High High
Immobilon 2 89.72 High High
long-term potentiation 42 87.84 High High
Disease Link Frequency Relevance Heat
Aggression 104 100.00 Very High Very High Very High
Sprains And Strains 410 99.98 Very High Very High Very High
Targeted Disruption 806 99.92 Very High Very High Very High
Sleep Disorders 10 99.92 Very High Very High Very High
Death 170 99.16 Very High Very High Very High
Neurodegenerative Disease 108 99.08 Very High Very High Very High
Disease 465 99.02 Very High Very High Very High
Depression 152 98.74 Very High Very High Very High
Apoptosis 97 98.72 Very High Very High Very High
Amnesia 21 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glycogen synthase kinase-3 (GSK3) has been recognized as an important enzyme that modulates many aspects of neuronal function.
GSK3 Binding (recognized) of in neuronal
1) Confidence 0.48 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16672106 Disease Relevance 0.36 Pain Relevance 0.08
Glycogen synthase kinase-3 (GSK3) has been recognized as an important enzyme that modulates many aspects of neuronal function.
Glycogen synthase kinase-3 Binding (recognized) of in neuronal
2) Confidence 0.48 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16672106 Disease Relevance 0.36 Pain Relevance 0.08
Decreased social interaction and aggression in GSK-3?
GSK-3 Binding (interaction) of associated with aggression
3) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.57 Pain Relevance 0.30
We observed changes associated with social interactions in GSK-3?
GSK-3 Binding (interactions) of
4) Confidence 0.44 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.48 Pain Relevance 0.22
deficiency on circadian rhythmicity were investigated in GSK3?
GSK3 Binding (investigated) of
5) Confidence 0.35 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.07 Pain Relevance 0
Generation of stable mouse embryonic fibroblast lines with GSK3?
GSK3 Binding (lines) of in fibroblast
6) Confidence 0.35 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0 Pain Relevance 0
Mice heterozygous for GSK-3?
GSK-3 Binding (heterozygous) of
7) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.96 Pain Relevance 0.44
Compared to WT littermates, GSK-3?
GSK-3 Binding (Compared) of
8) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.38 Pain Relevance 0.38
These data indicate that GSK-3?
GSK-3 Binding (indicate) of
9) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.58 Pain Relevance 0.34
The mechanisms of GSK-3 regulation are not fully understood; precise control appears to be achieved by a combination of phosphorylation, localization, and interactions with GSK-3-binding proteins [6].
GSK-3-binding Binding (interactions) of
10) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.12 Pain Relevance 0
Recent studies by Kimura et al. [53] have shown the importance of GSK-3?
GSK-3 Binding (importance) of
11) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.90 Pain Relevance 0.45
Gsk3b is a proline-directed serine-threonine kinase that was initially identified for its role phosphorylating and inactivating glycogen synthase [22].
Gsk3b Binding (proline) of
12) Confidence 0.31 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2346558 Disease Relevance 0 Pain Relevance 0
The Silencer™ Express siRNA expression cassette (SEC) kit (Ambion) was used to create a SEC for GSK3?
GSK3 Binding (create) of
13) Confidence 0.31 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0 Pain Relevance 0
(27C10) rabbit mAb, phospho-GSK3?
GSK3 Binding (rabbit) of
14) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0 Pain Relevance 0.04
has been reported to be involved in the PI3K/Akt pathway [25] and phosphorylated Akt inhibits the activity of GSK3?
GSK3 Binding (activity) of
15) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.04 Pain Relevance 0.07
The mechanism underlying decreased social behavior in GSK-3?
GSK-3 Binding (behavior) of
16) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.50 Pain Relevance 0.06
Recently, we found that one p75NTR missense polymorphism (S250L) was associated with the antidepressant response,53 and TrkB genetic variants may interact with the BDNF Val66Met polymorphism to contribute to the risk of geriatric depression.54 We also found that SNPs in glycogen synthase kinase-3beta (GSK3B), an important component in BDNF signaling, were associated with the therapeutic effects of antidepressants.55 In another study, we showed that genetic variants in plasminogen activator inhibitor type 1 gene (SERPINE1), which may be involved in the cleavage of proBDNF to mature BDNF in the brain,56 are related to MDD susceptibility and also the acute therapeutic response to antidepressants.57
GSK3B Binding (associated) of in cleavage associated with antidepressant and depression
17) Confidence 0.29 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.24 Pain Relevance 0.47
in the liver, hepatocyte-specific GSK-3?
GSK-3 Binding (hepatocyte) of in hepatocyte
18) Confidence 0.29 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.60 Pain Relevance 0.09
expression is restricted to skeletal muscle tissue only and remains unaltered in brain, heart, liver and testes of mice when compared to GSK-3?
GSK-3 Binding (compared) of in brain
19) Confidence 0.29 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.42 Pain Relevance 0.06
These observations led us to examine whether there are strain-specific effects associated with the ability of GSK-3?
GSK-3 Binding (ability) of associated with sprains and strains
20) Confidence 0.29 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.26 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox