INT135383

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.75
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (4930519F16Rik) molecular_function (4930519F16Rik) cellular_component (4930519F16Rik)
biological_process (4930519F16Rik)
4930519F16Rik (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 99.74 Very High Very High Very High
Pain 6 95.60 Very High Very High Very High
metalloproteinase 1 90.40 High High
agonist 4 86.08 High High
imagery 100 81.12 Quite High
Neuropeptide 2 65.20 Quite High
substance P 1 64.08 Quite High
Calcitonin gene-related peptide 1 62.80 Quite High
Dorsal horn 1 46.56 Quite Low
Spinal cord 1 45.04 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 99.74 Very High Very High Very High
Injury 9 99.16 Very High Very High Very High
Gastrointestinal Disease 1 98.92 Very High Very High Very High
Cholecystitis 1 96.84 Very High Very High Very High
Pain 3 95.60 Very High Very High Very High
Nociception 1 94.48 High High
Hypoxia 11 83.48 Quite High
Cancer 70 83.16 Quite High
Increased Venous Pressure Under Development 2 78.64 Quite High
Targeted Disruption 19 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proteases that activate PARs are often generated and secreted during injury and inflammation, and PARs orchestrate tissue responses to these insults, including hemostasis, inflammation, nociception, and repair mechanisms.
Positive_regulation (generated) of proteases associated with nociception, inflammation and injury
1) Confidence 0.01 Published 2006 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 16673265 Disease Relevance 0.78 Pain Relevance 0.46
Inflammation induces the activation of proteases that can signal to cells by cleaving protease-activated receptors (PARs) to induce hemostasis, inflammation, pain, and repair.
Positive_regulation (activation) of proteases associated with pain and inflammation
2) Confidence 0.01 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17431214 Disease Relevance 0.49 Pain Relevance 0.23
The first protease-sensing optical probes were autoquench fluorescent probes that convert from a nonfluorescent to a fluorescent state by proteolytic activation of lysosomal cysteine or serine proteases like cathepsin-B [67].
Positive_regulation (activation) of proteases
3) Confidence 0.00 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.48 Pain Relevance 0.09

General Comments

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