INT135387

Context Info Confidence 0.58 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.79 Pain Relevance 0.46

mitochondrion (Pars2) translation (Pars2) ligase activity (Pars2) cytoplasm (Pars2)

Pars2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 8 99.24 agonist 1 87.12 Pain 5 75.00 Neuropeptide 2 66.24 substance P 1 65.12 Calcitonin gene-related peptide 1 63.84 Dorsal horn 1 47.60 Spinal cord 1 46.08 antagonist 1 26.56

Disease Link Frequency Relevance Heat Injury 1 99.68 INFLAMMATION 6 99.24 Nociception 1 95.00 Increased Venous Pressure Under Development 1 79.68 Pain 2 75.00 Disease 1 31.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The proteases that activate PARs are often generated and secreted during injury and inflammation, and PARs orchestrate tissue responses to these insults, including hemostasis, inflammation, nociception, and repair mechanisms.

Localization (secreted) of PARs associated with nociception, inflammation and injury

1) Confidence 0.58 Published 2006 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 16673265 Disease Relevance 0.79 Pain Relevance 0.46

General Comments

This test has worked.