INT13539

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 22.55
Pain Relevance 8.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LTA) extracellular space (LTA) extracellular region (LTA)
cell-cell signaling (LTA)
Anatomy Link Frequency
erythrocyte 2
lumen 2
muscles 1
brain 1
basophil 1
LTA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 279 100.00 Very High Very High Very High
cytokine 201 100.00 Very High Very High Very High
antagonist 70 100.00 Very High Very High Very High
corticosteroid 284 99.68 Very High Very High Very High
Neuritis 22 99.48 Very High Very High Very High
Sciatic nerve 4 99.24 Very High Very High Very High
metalloproteinase 1 99.24 Very High Very High Very High
rheumatoid arthritis 51 98.24 Very High Very High Very High
Pain 19 98.24 Very High Very High Very High
cINOD 36 97.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 332 100.00 Very High Very High Very High
Diabetes Mellitus 121 100.00 Very High Very High Very High
Cancer 94 100.00 Very High Very High Very High
Necrosis 21 100.00 Very High Very High Very High
Staphylococcus Infection 27 99.96 Very High Very High Very High
Syndrome 512 99.88 Very High Very High Very High
Cytomegalovirus Infection 40 99.60 Very High Very High Very High
Experimental Autoimmune Neuritis 22 99.48 Very High Very High Very High
Disease 191 99.38 Very High Very High Very High
Sprains And Strains 86 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of LT synthesis by SASP and SP could contribute to the second line efficacy of SASP therapy in rheumatoid arthritis.
Gene_expression (synthesis) of LT associated with rheumatoid arthritis
1) Confidence 0.62 Published 1991 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 1673814 Disease Relevance 0.55 Pain Relevance 0.25
While B cells produce pro-inflammatory cytokines such as IL-6, IL-12 and lymphotoxin, and play a role in antigen-presentation [32], they were also reported to have tissue-protective and anti-inflammatory capacities in MS including the release of neurotrophic factors such as nerve growth factor or brain-derived neurotrophic factor [33], [34].
Gene_expression (produce) of lymphotoxin in brain associated with multiple sclerosis, nerve growth factor, inflammation and cytokine
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.05 Pain Relevance 0.62
Therefore, we could not test whether LTA, TNF and AGER polymorphisms are in linkage disequilibrium in type 1 diabetic patients as suggested by Laki et. al. who recently showed that the HLA 8.1 ancestral haplotype (8.1 AH) was strongly linked to the AGER -429T?
Gene_expression (polymorphisms) of LTA associated with diabetes mellitus
3) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429972 Disease Relevance 0.67 Pain Relevance 0
It has already been demonstrated that several ETEC antigens including LT-B can be expressed in live attenuated Salmonella strains and immune responses can be elicited in animal models [3–7].
Gene_expression (expressed) of LT associated with sprains and strains
4) Confidence 0.48 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 1.00 Pain Relevance 0
Though had not been investigated in SJS/TEN, LTA was co-cited with HLA-C [27], implying a putative functional linkage of this gene to SJS/TEN through HLA-C.
Gene_expression (cited) of LTA associated with staphylococcus infection and syndrome
5) Confidence 0.48 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2704868 Disease Relevance 1.43 Pain Relevance 0.04
There is evidence of enhanced LT production in the pathogenesis of AD.
Gene_expression (production) of LT
6) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945673 Disease Relevance 1.20 Pain Relevance 0.20
Patients with AD have activated circulating basophils and increased basophil and neutrophil releasability of LT-C4 compared with healthy subjects [10, 11], while urinary levels of LT-E4, a stable metabolite of LT-C4 and LT-D4, has been showed high levels in children affected by severe atopic eczema, but not in healthy normal subjects or in patients with mild or moderate atopic eczema [12].
Gene_expression (levels) of LT in neutrophil associated with skin allergy
7) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945673 Disease Relevance 1.12 Pain Relevance 0.22
ELISA and ELISPOT assays for heat labile toxin (LT) specific serum IgG antibody and IgA ASC responses
Gene_expression (responses) of LT
8) Confidence 0.41 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0 Pain Relevance 0
In addition, a SPI-2-associated in vivo inducible ssaG promoter was used to drive the expression of LT-B [24].
Gene_expression (expression) of LT
9) Confidence 0.37 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.28 Pain Relevance 0
ETEC may produce either or both of a heat labile enterotoxin (LT) and a heat stable enterotoxin (ST).
Gene_expression (produce) of LT
10) Confidence 0.37 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.26 Pain Relevance 0.05
This strain was subsequently used as a vector to express LT-B, which resulted in potent anti-LT responses in mice following intranasal and subcutaneous administration [7,22].
Gene_expression (express) of LT associated with sprains and strains
11) Confidence 0.37 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.31 Pain Relevance 0
Therefore, our observation that 67% of all volunteers demonstrated an IgG or IgA immune response against ETEC LT measured either by ELISPOT or ELISA, independent of dose level, is the first demonstration in a human trial to our knowledge that a recombinant S. typhi can effectively prime for a humoral response to a heterologous antigen in humans.
Gene_expression (response) of LT
12) Confidence 0.36 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.31 Pain Relevance 0
In conclusion, this pilot human study has shown that a 108 or 109 dose of live attenuated S. typhi expressing ETEC LT antigen is well tolerated, and highly immunogenic, inducing humoral immune responses to the inserted antigen in around two-thirds of subjects immunized orally after one or two doses.



Gene_expression (expressing) of LT
13) Confidence 0.32 Published 2007 Journal Vaccine Section Body Doc Link PMC2652036 Disease Relevance 0.09 Pain Relevance 0
Masseter (LMM, 17.05; RMM, 16.30), and the anterior temporalis muscles (LTA, 17.81; RTA, 17.69) were activated during swallowing, but had a lower SEMG value than the submental group.
Gene_expression (value) of LTA in muscles
14) Confidence 0.32 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0 Pain Relevance 0
It remains to be established why low-dose n-3 LCPUFA supplementation promotes production of LT but not the other T-cell cytokines, IFN?
Gene_expression (production) of LT in T-cell associated with cytokine
15) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.22 Pain Relevance 0.19
, LT production was increased in the n-3 LCPUFA-supplemented group compared with placebo at 6 months.
Gene_expression (production) of LT
16) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.11 Pain Relevance 0.11
In contrast, LT production by PHA-stimulated MNL was much greater in the n-3-supplemented group compared with placebo (Figure 5) and showed a significant and positive correlation with EPA erythrocyte content (Table 1, Figure 5).


Gene_expression (production) of LT in erythrocyte
17) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0 Pain Relevance 0.05
It does this possibly by reducing the production of leukotriene (LT)B4 synthase and LTC4, inhibiting phospholipase A2 and LTC4 (Hamasaki et al 1996).
Gene_expression (production) of LT
18) Confidence 0.30 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621402 Disease Relevance 1.25 Pain Relevance 0.22
Nevertheless, such increases in LT production can be protective against tissue damage in RA.
Gene_expression (production) of LT associated with rheumatoid arthritis
19) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.29 Pain Relevance 0.23
The discrepancy in the pattern of regression – that is, linear in the case of LT or U-shaped in that of PHA-induced proliferation – suggests that the proliferation response is more complex in terms of sensitivity to the membrane content of fatty acids compared to the production of LT.
Gene_expression (production) of LT
20) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.19 Pain Relevance 0.18

General Comments

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