INT135390

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.91
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) plasma membrane (Cd44) nucleus (Cd44)
protein complex (Cd44)
Cd44 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 5 98.20 Very High Very High Very High
metalloproteinase 6 96.74 Very High Very High Very High
Inflammation 33 92.16 High High
chemokine 19 74.56 Quite High
Crohn's disease 1 70.00 Quite High
Arthritis 2 69.32 Quite High
Osteoarthritis 2 63.72 Quite High
cytokine 7 52.92 Quite High
Pain 1 48.24 Quite Low
Inflammatory mediators 1 31.20 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 2 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 5 98.20 Very High Very High Very High
Metastasis 1 97.84 Very High Very High Very High
Osteoarthritis 3 97.36 Very High Very High Very High
Cancer 2 97.28 Very High Very High Very High
INFLAMMATION 34 92.16 High High
Disease 3 70.00 Quite High
Arthritis 2 69.32 Quite High
Injury 6 61.44 Quite High
Urinary Tract Infection 1 55.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD44, a major cell adhesion molecule, plays crucial roles as an anchor between cells and extracellular matrices by binding hyaluronan (HA) for the development of organs or the metastasis of tumors.
CD44 Binding (binding) of associated with cancer, metastasis and adhesions
1) Confidence 0.45 Published 2006 Journal The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Section Abstract Doc Link 16673425 Disease Relevance 0.75 Pain Relevance 0.36
MIF binds to cell-surface CD74 [15] and the MIF-CD74 complex then activates signal transduction by binding to another cell-surface receptor, CD44 [14].
CD44 Binding (binding) of
2) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.00 Pain Relevance 0.45
Hyaluronan inhibited interleukin-1beta-induced metalloproteinase production from osteoarthritic synovial tissue by a process that was not solely dependent on hyaluronan molecular mass but that was partly mediated by hyaluronan binding to CD44.
CD44 Binding (binding) of associated with metalloproteinase and osteoarthritis
3) Confidence 0.07 Published 2007 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 18090474 Disease Relevance 0.16 Pain Relevance 0.28

General Comments

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