INT135396

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 0.69
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
Caco-2 4
intestine 4
brain 3
lung 1
kidney 1
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 23 100.00 Very High Very High Very High
Bile 11 97.32 Very High Very High Very High
Bioavailability 4 87.84 High High
Buprenorphine 6 75.00 Quite High
methadone 6 75.00 Quite High
agonist 2 71.88 Quite High
Central nervous system 3 48.32 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
vincristine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 1 98.64 Very High Very High Very High
Targeted Disruption 15 94.12 High High
Liver Disease 2 73.36 Quite High
Infection 30 72.88 Quite High
Cancer 67 66.96 Quite High
Congenital Anomalies 3 47.28 Quite Low
Pressure And Volume Under Development 3 46.56 Quite Low
Hyperplasia 3 45.24 Quite Low
Hydrothorax 6 37.96 Quite Low
Leukemoid Reaction 3 25.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a mouse model, the effects of gestational age on P-gp and MRP expression in the placenta and brain were evaluated.
Regulation (effects) of Gene_expression (expression) of P-gp in brain
1) Confidence 0.60 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19116954 Disease Relevance 0 Pain Relevance 0.29
Dietary regulation of P-gp function and expression.
Regulation (regulation) of Gene_expression (expression) of P-gp
2) Confidence 0.58 Published 2009 Journal Expert Opin Drug Metab Toxicol Section Title Doc Link 19545213 Disease Relevance 0 Pain Relevance 0.15
The aim of the present study was to evaluate the chronicity and reversibility of the modulating effect of capsaicin on both the P-gp expression and activity in the Caco-2 cell monolayers.
Regulation (effect) of Gene_expression (expression) of P-gp in Caco-2 associated with qutenza
3) Confidence 0.49 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.56
Effects of capsaicin on P-gp function and expression in Caco-2 cells.
Regulation (Effects) of Gene_expression (expression) of P-gp in Caco-2 associated with qutenza
4) Confidence 0.36 Published 2006 Journal Biochem. Pharmacol. Section Title Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.85
Using a mouse model, the effects of gestational age on P-gp and MRP expression in the placenta and brain were evaluated.
Regulation (effects) of in placenta Gene_expression (expression) of P-gp in brain
5) Confidence 0.20 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19116954 Disease Relevance 0 Pain Relevance 0.29
The expression level of the h-MDR3 gene affects the development of hepatobiliary diseases [69].
Regulation (affects) of Gene_expression (expression) of h-MDR3 associated with disease
6) Confidence 0.18 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.27 Pain Relevance 0.13
On Day 7 after BMT, expression of human MDR1 and P-gp could be detected in kidney, lung and intestine of mice in group A and C (Figure 4).
Regulation (detected) of Gene_expression (expression) of P-gp in intestine
7) Confidence 0.06 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.14 Pain Relevance 0
On Day 7 after BMT, expression of human MDR1 and P-gp could be detected in kidney, lung and intestine of mice in group A and C (Figure 4).
Regulation (detected) of in kidney Gene_expression (expression) of P-gp in intestine
8) Confidence 0.02 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.14 Pain Relevance 0
On Day 7 after BMT, expression of human MDR1 and P-gp could be detected in kidney, lung and intestine of mice in group A and C (Figure 4).
Regulation (detected) of in lung Gene_expression (expression) of P-gp in intestine
9) Confidence 0.02 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.14 Pain Relevance 0

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