INT135398

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.53
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1a) ATPase activity (Abcb1a) plasma membrane (Abcb1a)
transmembrane transport (Abcb1a)
Anatomy Link Frequency
livers 2
SK-MEL-3 1
Caco-2 1
Abcb1a (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 11 98.36 Very High Very High Very High
Bile 22 78.16 Quite High
Bioavailability 1 50.24 Quite High
agonist 4 8.92 Low Low
diclofenac 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 41 99.32 Very High Very High Very High
Metastasis 4 95.40 Very High Very High Very High
Plasmacytoma 2 93.32 High High
Osteogenic Sarcomas 1 92.64 High High
Liver Cancer 4 84.40 Quite High
Skin Cancer 16 77.04 Quite High
Disease 3 62.68 Quite High
Pathologic Processes 2 58.00 Quite High
Liver Disease 4 52.60 Quite High
Shock 10 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice with RIs of 60–80% were fed a standard laboratory chow containing 0.3% (wt/wt) BF for 7 days, and their livers were analyzed for MDR3 mRNA and protein expression [39].
Spec (analyzed) Transcription (expression) of MDR3 in livers
1) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.20 Pain Relevance 0.08
Mice with RIs of 60–80% were fed a standard laboratory chow containing 0.3% (wt/wt) BF for 7 days, and their livers were analyzed for MDR3 mRNA and protein expression [39].
Spec (analyzed) Transcription (expression) of MDR3 in livers
2) Confidence 0.53 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.20 Pain Relevance 0.08
In contrast, longer term (48 and 72 h) co-incubation of the Caco-2 cells with capsaicin (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.
Transcription (levels) of P-gp protein in Caco-2 associated with qutenza
3) Confidence 0.19 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16674925 Disease Relevance 0 Pain Relevance 0.73
Cytostatic pretreatment can also be correlated with the presence of mdr1-mRNA and p-gp in the SK-MEL-3 tumor because the incidence of mdr1 expression has been observed to increase following previous chemotherapy, for example, in acute myeloic leucemia, plasmocytoma, or osteosarcoma, and adversely influences adversely remission rate and prognosis of relapsed tumors [21].
Transcription (presence) of p-gp in SK-MEL-3 associated with plasmacytoma, cancer and osteogenic sarcomas
4) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 1.14 Pain Relevance 0

General Comments

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