INT1354

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Context Info
Confidence 0.43
First Reported 1976
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 87
Total Number 87
Disease Relevance 15.01
Pain Relevance 36.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
hippocampus 4
brain 3
NAc 3
cortex 2
SOL 2
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 28 100.00 Very High Very High Very High
Somatostatin 25 100.00 Very High Very High Very High
Glutamate 17 100.00 Very High Very High Very High
Opioid 49 99.98 Very High Very High Very High
gABA 22 99.92 Very High Very High Very High
opiate 25 99.86 Very High Very High Very High
tetrodotoxin 40 99.84 Very High Very High Very High
methadone 8 99.84 Very High Very High Very High
Dopamine 51 99.80 Very High Very High Very High
Hippocampus 45 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 34 100.00 Very High Very High Very High
Convulsion 14 99.96 Very High Very High Very High
Diabetes Mellitus 26 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 32 99.64 Very High Very High Very High
Multiple System Atrophy 8 99.60 Very High Very High Very High
Cirrhosis 40 98.74 Very High Very High Very High
Cognitive Disorder 30 98.72 Very High Very High Very High
Hypoxia 9 98.24 Very High Very High Very High
Aging 5 98.00 Very High Very High Very High
Porphyria 4 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After microinjection of the neurotoxin 6-hydroxydopamine (6 micrograms/3 microliters, 7 days before) in the substantia nigra, the morphine (10 mg/kg)-induced decrease of ACh was attenuated, and a similar result occurred following reserpine (2 mg/kg, i.p.) 24 h before combined with alpha-methyl-p-tyrosine (300 mg/kg, i.p.) 2.5 h before.
Negative_regulation (decrease) of ACh in substantia nigra associated with substantia nigra and morphine
1) Confidence 0.43 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8095326 Disease Relevance 0 Pain Relevance 0.76
However, when these rats were administered chloral hydrate (400 mg/kg i.p.), the level of ACh was decreased immediately by 50%, attaining a value of 0.06 microM within 20-40 min following the injection.
Negative_regulation (decreased) of ACh
2) Confidence 0.43 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2157598 Disease Relevance 0 Pain Relevance 0
These results support the suggestion that barbiturates primarily inhibit the Ca-dependent stimulated release of ACh and affect ACh synthesis only indirectly.
Negative_regulation (inhibit) of ACh
3) Confidence 0.43 Published 1980 Journal Neurochem. Res. Section Abstract Doc Link 6968410 Disease Relevance 0 Pain Relevance 0.16
Moreover, oxotremorine, but not pilocarpine, inhibited ACh release in a concentration-dependent manner in either basal- or picric acid-evoked conditions, indicating the presence of muscarinic M2-receptors for auto-regulation of ACh release.
Negative_regulation (inhibited) of ACh
4) Confidence 0.43 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 2875422 Disease Relevance 0 Pain Relevance 0.23
Inhalational general anesthetics have recently been shown to inhibit neuronal nicotinic acetylcholine (ACh) receptors (nnAChRs) expressed in Xenopus laevis oocytes and in molluscan neurons.
Negative_regulation (inhibit) of ACh in oocytes
5) Confidence 0.40 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11259617 Disease Relevance 0 Pain Relevance 0.08
Given our previous findings of accentuated inhibition of ACh release by 5-HT3 agonism in striata of pCOC-exposed adult rats, we hypothesized that superfusion of endogenous and exogenous 5-HT would lead to greater suppression of evoked ACh release in this group of animals.
Negative_regulation (suppression) of ACh
6) Confidence 0.39 Published 2002 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12502023 Disease Relevance 0 Pain Relevance 0.71
The effects of oxotremorine and the cyclic GMP derivatives were not due to diminished ACh synthesis, since these compounds did not influence the reduction of tissue ACh resulting from treatment with K+ and atropine.
Negative_regulation (reduction) of ACh
7) Confidence 0.38 Published 1980 Journal Brain Res. Section Abstract Doc Link 6243230 Disease Relevance 0 Pain Relevance 0.09
Although striatal ACh content was no longer reduced in methadone-exposed rats, striatal cholinergic function remains disrupted.
Negative_regulation (reduced) of ACh associated with methadone
8) Confidence 0.38 Published 1991 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1786642 Disease Relevance 0.08 Pain Relevance 0.90
Systemic injection of morphine (20 mg/kg) significantly decreased ACh (30%, p less than .01) while it increased DA (55%, p less than .01).
Negative_regulation (decreased) of ACh associated with dopamine and morphine
9) Confidence 0.37 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1758589 Disease Relevance 0 Pain Relevance 0.88
When morphine and methylnaloxonium were given locally into the NAc by reverse dialysis, the opiate again decreased extracellular ACh, and the opiate antagonist increased it.
Negative_regulation (decreased) of ACh in NAc associated with nucleus accumbens, antagonist, opiate and morphine
10) Confidence 0.37 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8801582 Disease Relevance 0 Pain Relevance 1.28
In rats with microdialysis probes in the nucleus accumbens (NAc) or prefrontal cortex (PFC), intraperitoneally (IP) delivered morphine on the 8th day of escalating doses decreased extracellular ACh in the NAc.
Negative_regulation (decreased) of ACh in cortex associated with nucleus accumbens and morphine
11) Confidence 0.37 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8801582 Disease Relevance 0 Pain Relevance 1.00
The release of [3H]ACh was reduced by 85% when the Ca2+ concentration was changed from 2 to 0.1 mM.
Negative_regulation (reduced) of ACh
12) Confidence 0.37 Published 1986 Journal Acta Physiol. Scand. Section Abstract Doc Link 3019084 Disease Relevance 0 Pain Relevance 0.34
Polymyxin B (6 X 10(-5) M) and rolitetracycline (7 X 10(-4) M) blocked by 50% the response of rat diaphragm induced by phrenic nerve stimulation, but did not decrease the amount of acetylcholine (ACh) released from this preparation during nerve stimulation.
Neg (not) Negative_regulation (decrease) of ACh in nerve
13) Confidence 0.37 Published 1976 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 191167 Disease Relevance 0 Pain Relevance 0.09
Tetrodotoxin (1 microM) produced a significant decrease in the amount of ACh collected in the perfusate, suggesting that basal ACh determined under the present experimental conditions was related to cholinergic neural activity.
Negative_regulation (decrease) of ACh in neural associated with tetrodotoxin
14) Confidence 0.37 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1861156 Disease Relevance 0 Pain Relevance 0.10
Additionally, we demonstrated that methyllycaconitine (0.29 and 0.87 mg/kg i.p.), a selective inhibitor of alpha7 nicotinic acetylcholine (ACh) receptors (alpha7nAChRs), ablated the antiulcerogenic action of mosapride.
Negative_regulation (inhibitor) of ACh
15) Confidence 0.37 Published 2010 Journal J. Gastroenterol. Section Body Doc Link 20012106 Disease Relevance 0.14 Pain Relevance 0
CONCLUSIONS: Our findings showed that as a results of estrogen deficiency, Ach release from nerve fibres decreased, suggesting that this reduction of Ach released from cholinergic nerves may cause the decrease in detrusor contractility.
Negative_regulation (reduction) of Ach in nerves
16) Confidence 0.37 Published 2007 Journal Neurourol. Urodyn. Section Body Doc Link 17480029 Disease Relevance 0.05 Pain Relevance 0
Local perfusion of 1 mumol/l of the sodium-channel blocker tetrodotoxin (TTX) through the probe resulted in 94% and 92% decrease in extracellular levels of ACh in the hippocampus and the septal area, respectively.
Negative_regulation (decrease) of ACh in septal area associated with tetrodotoxin and hippocampus
17) Confidence 0.37 Published 1994 Journal Brain Res. Section Abstract Doc Link 7922524 Disease Relevance 0 Pain Relevance 0.50
In order to investigate the correlation between the peripheral ACh and the primary input of acupuncture sensation, in the paper the cholinesterase inhibitor--Neostigmine and the ACh synthesis blocker--Hemicholine, which are unable to pass through blood brain barrier, and ACh were used as tools to increase or decrease the level of ACh in peripheral nerve system of rats.
Negative_regulation (decrease) of ACh in peripheral nerve associated with acupuncture
18) Confidence 0.37 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2125863 Disease Relevance 0 Pain Relevance 0.57
At high concentrations, meptazinol, like morphine and fentanyl, reduced the sensitivity of the post-junctional membrane to ACh.
Negative_regulation (reduced) of ACh associated with morphine
19) Confidence 0.37 Published 1986 Journal Acta Physiol Pharmacol Latinoam Section Abstract Doc Link 2945403 Disease Relevance 0.07 Pain Relevance 0.81
In the cortex, serotonin (5-HT) failed to alter spontaneous ACh release, but caused a concentration-dependent decrease of K+-evoked ACh release.
Negative_regulation (decrease) of ACh in cortex associated with serotonin
20) Confidence 0.37 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618425 Disease Relevance 0.30 Pain Relevance 0.32

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