INT135407

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 32.74
Pain Relevance 9.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
microglia 3
monocyte 3
cardiac myocytes 2
grey matter 1
brain 1
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 768 100.00 Very High Very High Very High
chemokine 634 100.00 Very High Very High Very High
cytokine 592 100.00 Very High Very High Very High
Thermal hyperalgesia 1 99.90 Very High Very High Very High
Eae 16 99.40 Very High Very High Very High
Multiple sclerosis 353 98.92 Very High Very High Very High
dorsal root ganglion 4 97.16 Very High Very High Very High
Central nervous system 313 95.88 Very High Very High Very High
Inflammatory response 122 91.20 High High
Inflammatory mediators 39 91.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 966 100.00 Very High Very High Very High
Hyperalgesia 4 99.90 Very High Very High Very High
Cancer 72 99.86 Very High Very High Very High
Disorder Of Lipid Metabolism 23 99.84 Very High Very High Very High
Dementia 6 99.48 Very High Very High Very High
Multiple Sclerosis 581 99.40 Very High Very High Very High
Injury 85 99.40 Very High Very High Very High
Necrosis 74 99.30 Very High Very High Very High
Targeted Disruption 192 99.16 Very High Very High Very High
Hyperlipidemia 23 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mahad et al [64] also found that CCL2 in the CSF was decreased not only in patients with MS but also in patients with IND when compared to those of non-inflammatory CNS disease controls.
Negative_regulation (decreased) of CCL2 associated with multiple sclerosis, neurological disease, inflammation, central nervous system and disease
1) Confidence 0.57 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.08 Pain Relevance 0.46
to the periphery, and a decrease in the inflammatory cytokine MCP-1 (Figs. 7, 8, 9).
Negative_regulation (decrease) of MCP-1 associated with inflammation and cytokine
2) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 1.12 Pain Relevance 0.19
The CC chemokine ligand 2 (CCL2) may contribute to the tumor cell-induced sensitization because CCL2 immunoreactivity was present in tumors, high levels of CCL2 peptide were present in microperfusates from tumors, and treatment of DRG neurons in vitro with CCL2 increased the amount of mRNA for the alpha2delta1 subunit.
Negative_regulation (levels) of CCL2 in DRG associated with dorsal root ganglion, chemokine and cancer
3) Confidence 0.43 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17881535 Disease Relevance 1.72 Pain Relevance 0.82
The first consideration suggests, that the decreased CCL2 level likely relate to a decreased TH2 lymphocyte activity, as CCL2 induces TH2 polarization.
Negative_regulation (decreased) of CCL2 in lymphocyte
4) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.68 Pain Relevance 0.31
In contrast, decreased CCL2 was found in the CSF in all clinical forms of MS by Scarpini et al.[62] More consistently, however, low CCL2 levels were detected only during relapses by others [41,59,61,63,64].
Negative_regulation (decreased) of CCL2 associated with multiple sclerosis and recurrence
5) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.98 Pain Relevance 0.44
The consistently observed decrease in CCL2 levels in the CSF during or even prior to a relapse generated alternative considerations.
Negative_regulation (decrease) of CCL2 associated with recurrence
6) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.70 Pain Relevance 0.30
It has to be considered that the absence of TLR4, not only reduces infarct size, but also other regulatory proteins, such as the chemokine monocyte chemoattractant protein (MCP)-1, which may prolong inflammation and delay replacement of injured cardiac myocytes [30].
Negative_regulation (reduces) of MCP in cardiac myocytes associated with chemokine and inflammation
7) Confidence 0.41 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.69 Pain Relevance 0.53
While high numbers of MNCs expressing CCL2 and CCL5 were found in some patients, overall no differences were observed between MS and acute meningitis.
Negative_regulation (numbers) of CCL2 associated with multiple sclerosis and meningitis
8) Confidence 0.41 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.74 Pain Relevance 0.71
In tumor necrosis factor (TNF)-alpha-treated cells, suppression of MCP-1 by indomethacin was inversely correlated with induction of UPR, and other inducers of UPR including tunicamycin, thapsigargin, and A23187 reproduced the suppressive effect.
Negative_regulation (suppression) of MCP-1 associated with necrosis and cancer
9) Confidence 0.40 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.52 Pain Relevance 0.20
In the present experiments, CCL2 levels were lower in B2-/- mice than in WT mice after EAE induction.
Negative_regulation (lower) of CCL2 associated with multiple sclerosis
10) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.12 Pain Relevance 0.26
Blocking of the CCL2-CCR2 axis with neutralizing antibodies limits the development of subsequent relapses [54].
Negative_regulation (Blocking) of CCL2 associated with recurrence
11) Confidence 0.35 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.10 Pain Relevance 0.34
The deletion of the CCR2 [a receptor for monocyte chemoattractant protein-1 (MCP-1 or CCL2)] gene in Tg2576 mice reduced the number of microglia and impaired A?
Negative_regulation (monocyte) of MCP-1 in microglia
12) Confidence 0.34 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.04 Pain Relevance 0.06
The deletion of the CCR2 [a receptor for monocyte chemoattractant protein-1 (MCP-1 or CCL2)] gene in Tg2576 mice reduced the number of microglia and impaired A?
Negative_regulation (monocyte) of CCL2 in microglia
13) Confidence 0.34 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.04 Pain Relevance 0.06
levels, and found that MCP-1 decreased as soluble, insoluble, and total A?
Negative_regulation (decreased) of MCP-1
14) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 0.60 Pain Relevance 0.09
accompanied by a decrease in CNS MCP-1.


Negative_regulation (decrease) of MCP-1
15) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2955708 Disease Relevance 1.56 Pain Relevance 0.13
to IL-10, we also found a significant decrease in the CCL2/IL-10 ratio in serum samples from animals infected with CL Brener in the presence of JG.
Negative_regulation (decrease) of CCL2
16) Confidence 0.33 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2953483 Disease Relevance 0.91 Pain Relevance 0.21
For example, MC3R KO mice exhibit increased adiposity and nutrient partitioning in addition to impaired immune function, evidenced by decreased macrophage infiltration and decreased monocyte chemoattractant protein 1 (MCP-1) and chemokine of differentiation 68 (CD68) mRNA expression into adipose tissue in comparison to wild-type mice [16, 32].
Negative_regulation (decreased) of MCP-1 in monocyte associated with chemokine and obesity
17) Confidence 0.33 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.49 Pain Relevance 0.21
For example, MC3R KO mice exhibit increased adiposity and nutrient partitioning in addition to impaired immune function, evidenced by decreased macrophage infiltration and decreased monocyte chemoattractant protein 1 (MCP-1) and chemokine of differentiation 68 (CD68) mRNA expression into adipose tissue in comparison to wild-type mice [16, 32].
Negative_regulation (decreased) of monocyte chemoattractant protein 1 in monocyte associated with chemokine and obesity
18) Confidence 0.33 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.49 Pain Relevance 0.21
The immunized female mice had a significant 26% decrease in MCP-1 following treatment (p < 0.05) (Fig. 9A).
Negative_regulation (decrease) of MCP-1
19) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 0.48 Pain Relevance 0.09
MCP-1 is decreased, and is positively correlated with brain A?
Negative_regulation (decreased) of MCP-1 in brain
20) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 0.46 Pain Relevance 0.07

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