INT135408

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 10.70
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a) extracellular region (Il17a)
Anatomy Link Frequency
nerves 1
skin 1
lungs 1
optic nerve 1
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 52 100.00 Very High Very High Very High
Eae 6 99.86 Very High Very High Very High
cytokine 314 99.52 Very High Very High Very High
Inflammatory mediators 8 98.56 Very High Very High Very High
Inflammation 191 97.40 Very High Very High Very High
Inflammatory stimuli 8 97.36 Very High Very High Very High
Neuropathic pain 1 93.04 High High
Sciatic nerve 2 91.24 High High
Multiple sclerosis 48 90.32 High High
Crohn's disease 15 88.28 High High
Disease Link Frequency Relevance Heat
Injury 11 99.86 Very High Very High Very High
Systemic Sclerosis 60 99.76 Very High Very High Very High
INFLAMMATION 213 98.16 Very High Very High Very High
Systemic Lupus Erythematosus 89 95.00 High High
Immunization 3 94.56 High High
Inflammatory Bowel Disease 17 93.88 High High
Polymyositis 2 93.56 High High
Dermatomyositis 3 93.04 High High
Neuropathic Pain 1 93.04 High High
Multiple Sclerosis 75 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BALFs were harvested at different time points and the concentrations of IL-17A and IFN?
Transcription (concentrations) of IL-17A
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.41 Pain Relevance 0.12
The major lymphocyte sources for IL-17A are the unique Th17 cells, which are developed due to the function of the IL-23 cytokine, as well as the ??
Transcription (function) of IL-17A associated with cytokine
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.18 Pain Relevance 0.31
It was very recently shown that the IL-17A-producing ??
Transcription (shown) of IL-17A-producing
3) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.71 Pain Relevance 0
Concentrations of IL-4 protein in the optic nerve declined slightly in 19 days. mRNA expression of IL-17, IFN-gamma and IL-4 was consistent with their protein expression.
Transcription (expression) of IL-17 in optic nerve
4) Confidence 0.63 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20428790 Disease Relevance 0.79 Pain Relevance 0.36
IL-17A displayed a monophasic expression in degenerating nerves at day 7 after CCI while transcripts for the IL-17A regulatory cytokines IL-23 and IL-15 peaked earlier.
Transcription (transcripts) of IL-17A in nerves associated with eae and cytokine
5) Confidence 0.52 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16674943 Disease Relevance 0.97 Pain Relevance 0.69
In patients with systemic sclerosis (SSc) increased IL-17A messenger RNA was expressed in unstimulated PBMC and lymphocytes from the skin and lungs of SSc patients, but not in similar samples from patients with systemic lupus erythematosus (SLE), polymyositis/dermatomyositis, or from healthy donors (TableĀ 1).
Neg (not) Transcription (expressed) of IL-17A in lungs associated with dermatomyositis, polymyositis, systemic lupus erythematosus and systemic sclerosis
6) Confidence 0.42 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 2.00 Pain Relevance 0.47
, IL-2, IL-3, IL-4, IL-6, IL-10,IL-17, GM-CSF, KC, and Rantes were the best discriminators of the BCG response relative to TNF-?
Transcription (discriminators) of IL-17 associated with chemokine
7) Confidence 0.34 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.53 Pain Relevance 0.31
We could show increased mRNA expression levels of both IL-23 and IL-17 upon TNBS treatment, which were greatly reduced by Lr32-pulsed DCs.
Transcription (expression) of IL-17
8) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.07 Pain Relevance 0.29
In patients with systemic sclerosis (SSc) increased IL-17A messenger RNA was expressed in unstimulated PBMC and lymphocytes from the skin and lungs of SSc patients, but not in similar samples from patients with systemic lupus erythematosus (SLE), polymyositis/dermatomyositis, or from healthy donors (TableĀ 1).
Neg (not) Transcription (expressed) of IL-17A in skin associated with dermatomyositis, polymyositis, systemic lupus erythematosus and systemic sclerosis
9) Confidence 0.14 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 2.00 Pain Relevance 0.47
This included transcripts for IL-8, IL-17 receptor, STAT1, and TRAIL.
Transcription (transcripts) of IL-17
10) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.03 Pain Relevance 0.38

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