INT135409

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 10.59
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 2
mesentery 2
microglia 2
adipose tissue 1
F4/80 1
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 415 100.00 Very High Very High Very High
cytokine 183 100.00 Very High Very High Very High
metalloproteinase 20 100.00 Very High Very High Very High
Inflammation 567 99.74 Very High Very High Very High
Thermal hyperalgesia 1 99.64 Very High Very High Very High
Eae 6 99.40 Very High Very High Very High
Inflammatory response 29 91.20 High High
Peripheral nerve injury 1 88.96 High High
Multiple sclerosis 244 82.32 Quite High
Spinal cord 32 78.68 Quite High
Disease Link Frequency Relevance Heat
Obesity 62 99.76 Very High Very High Very High
INFLAMMATION 611 99.74 Very High Very High Very High
Hyperalgesia 1 99.64 Very High Very High Very High
Injury 38 99.40 Very High Very High Very High
Disease 329 98.44 Very High Very High Very High
Recurrence 64 98.08 Very High Very High Very High
Adhesions 90 97.28 Very High Very High Very High
Wound Healing 1 97.00 Very High Very High Very High
Multiple Sclerosis 318 94.88 High High
Inflammatory Bowel Disease 2 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
I/R-induced changes in KC (CXCL1) and MCP-1 (CCL2) protein expression in the mesentery were paralleled by changes in mRNA levels, as detected by real-time PCR.
Transcription (expression) of MCP-1 in mesentery
1) Confidence 0.62 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.07 Pain Relevance 0.16
I/R-induced changes in KC (CXCL1) and MCP-1 (CCL2) protein expression in the mesentery were paralleled by changes in mRNA levels, as detected by real-time PCR.
Transcription (expression) of CCL2 in mesentery
2) Confidence 0.62 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.07 Pain Relevance 0.16
The deletion of the CCR2 [a receptor for monocyte chemoattractant protein-1 (MCP-1 or CCL2)] gene in Tg2576 mice reduced the number of microglia and impaired A?
Transcription (receptor) of CCL2 in microglia
3) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.05 Pain Relevance 0.09
The deletion of the CCR2 [a receptor for monocyte chemoattractant protein-1 (MCP-1 or CCL2)] gene in Tg2576 mice reduced the number of microglia and impaired A?
Transcription (receptor) of MCP-1 in microglia
4) Confidence 0.56 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.05 Pain Relevance 0.09
For example, MC3R KO mice exhibit increased adiposity and nutrient partitioning in addition to impaired immune function, evidenced by decreased macrophage infiltration and decreased monocyte chemoattractant protein 1 (MCP-1) and chemokine of differentiation 68 (CD68) mRNA expression into adipose tissue in comparison to wild-type mice [16, 32].
Transcription (expression) of MCP-1 in monocyte associated with chemokine and obesity
5) Confidence 0.55 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.44 Pain Relevance 0.18
Conversely, Trevaskis et al. have shown an increase in macrophage infiltration and increases in and CD68 and MCP-1 mRNA expression within the adipose tissue in MC3R KO mice compared to control [33].
Transcription (expression) of MCP-1 in adipose tissue associated with obesity
6) Confidence 0.55 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.42 Pain Relevance 0.16
For example, MC3R KO mice exhibit increased adiposity and nutrient partitioning in addition to impaired immune function, evidenced by decreased macrophage infiltration and decreased monocyte chemoattractant protein 1 (MCP-1) and chemokine of differentiation 68 (CD68) mRNA expression into adipose tissue in comparison to wild-type mice [16, 32].
Transcription (expression) of monocyte chemoattractant protein 1 in monocyte associated with chemokine and obesity
7) Confidence 0.53 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.50 Pain Relevance 0.21
Youseff et al [16] observed an increased mRNA transcription not only for MCP-1 (CCL2), but also for MIP-1?
Transcription (transcription) of CCL2
8) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.36 Pain Relevance 0.10
Youseff et al [16] observed an increased mRNA transcription not only for MCP-1 (CCL2), but also for MIP-1?
Transcription (transcription) of MCP-1
9) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.36 Pain Relevance 0.10
While most of the above studies used the method of immunohistochemistry, we recently assessed the mRNA expression levels for CCL2, CCL3, CCL5, CCL7, CCL8, CCL13 and CCL15 relative to ?
Transcription (levels) of CCL2
10) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.29 Pain Relevance 0.22
While most of the above studies used the method of immunohistochemistry, we recently assessed the mRNA expression levels for CCL2, CCL3, CCL5, CCL7, CCL8, CCL13 and CCL15 relative to ?
Transcription (expression) of CCL2
11) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.29 Pain Relevance 0.22
1, CCL2, VEGF, MMP-9 and TIMP-2 protein and mRNA expression (Saika et al 2005).
Transcription (expression) of CCL2 associated with metalloproteinase
12) Confidence 0.32 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.26 Pain Relevance 0.22
This was paralleled by significant higher mRNA levels of the proinflammatory cytokines MCP1 and IL-6 (Figure 3F).
Transcription (levels) of MCP1 associated with cytokine
13) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.29 Pain Relevance 0.15
To index the inflammatory state, mRNA levels of ICAM-1 and MCP-1 were determined.
Transcription (levels) of MCP-1 associated with inflammation
14) Confidence 0.23 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 1.14 Pain Relevance 0.19
Interestingly, T cell deficiency was associated with less thermal hyperalgesia and reduced mRNA levels for the macrophage marker molecule F4/80 and the chemokine macrophage chemoattractant protein-1 (MCP-1) after CCI.
Transcription (levels) of chemokine macrophage chemoattractant protein-1 in F4/80 associated with chemokine, eae and thermal hyperalgesia
15) Confidence 0.23 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16674943 Disease Relevance 0.98 Pain Relevance 0.83

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