INT13541

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Context Info
Confidence 0.51
First Reported 1991
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.01
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (LTC4S) nuclear envelope (LTC4S) small molecule metabolic process (LTC4S)
lyase activity (LTC4S) endoplasmic reticulum (LTC4S) nucleus (LTC4S)
Anatomy Link Frequency
joint 2
basophils 2
LTC4S (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6 98.36 Very High Very High Very High
Osteoarthritis 2 96.60 Very High Very High Very High
Versed 2 88.32 High High
Buprenorphine 2 85.28 High High
Morphine 2 84.68 Quite High
Opioid 1 84.28 Quite High
ketamine 2 83.24 Quite High
cINOD 2 71.68 Quite High
Disease Link Frequency Relevance Heat
Arthropathy 2 98.88 Very High Very High Very High
Rheumatoid Arthritis 6 98.36 Very High Very High Very High
Chondrocalcinosis 2 97.36 Very High Very High Very High
Osteoarthritis 2 96.60 Very High Very High Very High
INFLAMMATION 2 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcium ionophore A23187 significantly increased the release of PGE2, 6-keto-PGF1 alpha, LTB4, and LTC4 from human synovial tissue irrespective of the underlying joint disease.
Positive_regulation (increased) of Localization (release) of LTC4 in joint associated with arthropathy
1) Confidence 0.51 Published 1991 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 1673814 Disease Relevance 0.51 Pain Relevance 0.19
None of the drugs tested induced the release of histamine or LTC4 from basophils of normal donors.
Positive_regulation (induced) of Localization (release) of LTC4 in basophils
2) Confidence 0.37 Published 1993 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 7690200 Disease Relevance 0 Pain Relevance 0.37
SASP inhibited release of LTC4 and increased release of PGE2.
Positive_regulation (increased) of Localization (release) of LTC4
3) Confidence 0.30 Published 1991 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 1673814 Disease Relevance 0.51 Pain Relevance 0.20

General Comments

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