INT135411

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Context Info
Confidence 0.72
First Reported 2005
Last Reported 2011
Negated 1
Speculated 8
Reported most in Body
Documents 76
Total Number 93
Disease Relevance 72.87
Pain Relevance 26.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il23a) extracellular region (Il23a)
Anatomy Link Frequency
dendritic cells 8
monocytes 8
Th17 cells 7
macrophages 4
T cells 4
Il23a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2581 100.00 Very High Very High Very High
rheumatoid arthritis 1319 100.00 Very High Very High Very High
Inflammatory mediators 85 100.00 Very High Very High Very High
Crohn's disease 594 99.88 Very High Very High Very High
Inflammation 1650 99.44 Very High Very High Very High
Arthritis 808 99.32 Very High Very High Very High
Central nervous system 336 99.32 Very High Very High Very High
Eae 6 99.32 Very High Very High Very High
psoriasis 555 99.16 Very High Very High Very High
chemokine 357 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1748 100.00 Very High Very High Very High
Rheumatoid Arthritis 1325 100.00 Very High Very High Very High
Acanthosis 24 100.00 Very High Very High Very High
Disease 2044 99.88 Very High Very High Very High
Infection 817 99.80 Very High Very High Very High
Central Nervous System Disease 208 99.68 Very High Very High Very High
Systemic Sclerosis 269 99.66 Very High Very High Very High
Sprains And Strains 275 99.40 Very High Very High Very High
Arthritis 638 99.32 Very High Very High Very High
Autoimmune Disease 368 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-23 was found to be expressed by several activated human cells like monocytes, macrophages, DCs, T cells, B cells and endothelial cells.22,23 IL-23 binds to its heterodimeric receptor complex composed of the IL-12R?
Gene_expression (expressed) of IL-23 in macrophages
1) Confidence 0.72 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.50 Pain Relevance 0.18
Data from studies in deficient knockout mice or in mice following very high doses of neutralizing antibody administration suggest that IL-12 (Th1) and IL-23 (Th17) responses may contribute to protective immune responses to viral and bacterial pathogens.61,62 In contrast to observations in murine models, humans with genetic deficiencies in the Th1 and Th17 pathways, involving, among the others, IL-12/23p40, IL-12R?
Gene_expression (responses) of IL-23 associated with targeted disruption
2) Confidence 0.62 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.90 Pain Relevance 0
, IL23A and STAT3 was detected.
Gene_expression (detected) of IL23A
3) Confidence 0.60 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.00 Pain Relevance 0.46
In the colon, IL23A was expressed at higher levels in UC samples than in CD samples (P = 0.027).
Gene_expression (expressed) of IL23A in colon associated with inflammatory bowel disease and crohn's disease
4) Confidence 0.60 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 2.20 Pain Relevance 0.58
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Gene_expression (expression) of IL-23A in fibroblasts
5) Confidence 0.60 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.62 Pain Relevance 0.26
(P = 0.0008) and IL23A (P = 0.010) were expressed at higher levels in the colon than in the ileum.


Gene_expression (expressed) of IL23A in ileum
6) Confidence 0.60 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 2.26 Pain Relevance 0.58
In the present investigation, we analyzed the temporal gene expression pattern of IL-17A and its main regulators IL-23 and IL-15 after chronic constriction injury (CCI) of the sciatic nerve, a lesion paradigm inducing neuropathic pain, by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) in mice.
Spec (analyzed) Gene_expression (expression) of IL-23 in sciatic nerve associated with eae, injury, neuropathic pain and sciatic nerve
7) Confidence 0.47 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16674943 Disease Relevance 0.75 Pain Relevance 0.52
The present study assessed the mRNA expression levels of Th17 effector cytokines (IL17A, IL17F, IL21, IL22 and IL26) and genes involved in differentiation (IL6, IL1B, TGFB1, IL23A and STAT3) and recruitment of Th17 cells (CCR6 and CCL20) by quantitative real-time PCR analysis of colonic and ileal biopsies from 22 healthy control subjects, 26 patients with Crohn's disease (CD) and 12 patients with ulcerative colitis (UC).
Gene_expression (expression) of IL23A in Th17 cells associated with inflammatory bowel disease, crohn's disease, disease and cytokine
8) Confidence 0.46 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.90 Pain Relevance 0.35
and IL23A expression levels were similar in colonic and ileal control samples (Figure 1C).
Gene_expression (expression) of IL23A
9) Confidence 0.46 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.35 Pain Relevance 0.44
Although increased expression of IL17A, IL17F, IL21 and IL26 was detected in inflamed ileal samples, expression of the indispensable Th17 cell differentiation factors TGFB1 and IL23A, the signaling molecule STAT3 and the Th17 recruitment factors CCR6 and CCL20 were unchanged.


Gene_expression (expression) of IL23A in Th17 cell
10) Confidence 0.46 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.81 Pain Relevance 0.32
Collectively, these observations invite an alternative interpretation of the mechanism of action of IL-12p40 in neuroinflammation; namely, that its role is in the production of IL-23 and reinforcement of the Th17 effector cell population, rather than (or in addition to) the production of IL-12p70 and promotion of Th1 differentiation.
Gene_expression (production) of IL-23
11) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.46 Pain Relevance 0.10
Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis.
Gene_expression (Overexpression) of interleukin-23 associated with spinal inflammation and inflammation
12) Confidence 0.38 Published 2009 Journal Arthritis Rheum. Section Title Doc Link 19333939 Disease Relevance 0.56 Pain Relevance 0.39
IL-23 was abundantly produced by infiltrating monocyte-like cells in inflamed mucosa from AS and CD patients.
Gene_expression (produced) of IL-23 in monocyte
13) Confidence 0.38 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19333939 Disease Relevance 0.24 Pain Relevance 0
This study was undertaken to investigate the expression and tissue distribution of IL-23/Th17-related molecules in Crohn's disease (CD) and in subclinical gut inflammation in ankylosing spondylitis (AS).
Spec (investigate) Gene_expression (expression) of IL-23 in gut associated with spinal inflammation, inflammation, crohn's disease and disease
14) Confidence 0.38 Published 2009 Journal Arthritis Rheum. Section Abstract Doc Link 19333939 Disease Relevance 0.81 Pain Relevance 0.40
IL-23 tissue distribution and identification of IL-23-producing cells were evaluated by immunohistochemistry.
Gene_expression (producing) of IL-23
15) Confidence 0.38 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19333939 Disease Relevance 0.26 Pain Relevance 0
Deficiency of IL-17 or IL-23 (a heterodimeric monokine composed of IL-12p40 and p19 chains that expands and/or stabilizes Th17 cells) (6, 7) confers partial or complete resistance, respectively, against MOG35-55–induced EAE in C57BL/6 mice, whereas deficiency of IFN-?
Gene_expression (Deficiency) of IL-23 in Th17 cells associated with multiple sclerosis
16) Confidence 0.38 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 1.19 Pain Relevance 0.32
Adoptive transfer of either IL-12p70– or IL-23–polarized T cells into naive syngeneic hosts resulted in an ascending paralysis that was clinically indistinguishable between the two groups.
Gene_expression (transfer) of IL-23 in T cells associated with paralysis
17) Confidence 0.38 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442630 Disease Relevance 0.42 Pain Relevance 0.23
(BD Biosciences); IL-17A (R&D Systems); and IL-12/IL-23 p40, IL-1?
Gene_expression (/) of IL-23 p40
18) Confidence 0.35 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.09 Pain Relevance 0.18
Adoptive transfer of IL-12– and IL-23–modulated T cells induces distinct chemokine profiles in the inflamed CNS
Gene_expression (transfer) of IL-23 in T cells associated with chemokine and central nervous system
19) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 1.04 Pain Relevance 0.49
We harvested draining LN cells (LNCs) from SJL mice that had been primed with PLP139–151 in IFA and cultured them with antigen under either neutral conditions (i.e., with antigen and an anti–IL-12p40–neutralizing antibody), or conditions favorable to the generation of Th17 (IL-23, IL-1?
Gene_expression (generation) of IL-23
20) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.44 Pain Relevance 0.11

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