INT135412

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Trap1) protein folding (Trap1) mitochondrion (Trap1)
response to stress (Trap1)
Anatomy Link Frequency
dorsal root ganglia 2
Trap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 6 100.00 Very High Very High Very High
dorsal root ganglion 5 100.00 Very High Very High Very High
Thermal hyperalgesia 2 93.60 High High
allodynia 6 92.60 High High
Neuropathic pain 3 87.92 High High
Pain 3 37.36 Quite Low
neuralgia 3 25.00 Low Low
intrathecal 1 25.00 Low Low
Hyperesthesia 1 25.00 Low Low
Sciatic nerve 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 100.00 Very High Very High Very High
Nervous System Injury 1 99.72 Very High Very High Very High
Necrosis 3 99.40 Very High Very High Very High
Cancer 3 99.22 Very High Very High Very High
Hyperalgesia 2 93.60 High High
Neuropathic Pain 9 92.60 High High
Pain 1 37.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that immunoreactivity (IR) of TNF-alpha and TNF receptor 1 (TNFR1) in ipsilateral (but not in contralateral) L4 and L5 dorsal root ganglion (DRG) was increased following L5 VRT, started 1 day after the lesion and persisted for 2 weeks.
Positive_regulation (increased) of TNF receptor 1 in DRG associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.18 Published 2006 Journal Pain Section Abstract Doc Link 16675114 Disease Relevance 1.04 Pain Relevance 0.60
Previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) and TNF receptor 1 (TNFR1) in dorsal root ganglia (DRG) and in spinal dorsal horn are upregulated after nerve injury and that many TNF-alpha-containing neurons overexpress TNFR1.
Positive_regulation (upregulated) of TNF receptor 1 in dorsal root ganglia associated with necrosis, nervous system injury, cancer and spinal dorsal horn
2) Confidence 0.17 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17459378 Disease Relevance 0.45 Pain Relevance 0.24

General Comments

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