INT13543

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Context Info
Confidence 0.58
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.26
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (LTC4S) nuclear envelope (LTC4S) small molecule metabolic process (LTC4S)
lyase activity (LTC4S) endoplasmic reticulum (LTC4S) nucleus (LTC4S)
Anatomy Link Frequency
joint 1
LTC4S (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 9 99.20 Very High Very High Very High
Inflammatory marker 3 98.64 Very High Very High Very High
rheumatoid arthritis 3 98.36 Very High Very High Very High
Osteoarthritis 1 96.60 Very High Very High Very High
Analgesic 1 95.72 Very High Very High Very High
bradykinin 6 90.88 High High
qutenza 14 90.28 High High
adenocard 3 88.08 High High
primary afferent fibers 2 80.40 Quite High
Dopamine 1 75.60 Quite High
Disease Link Frequency Relevance Heat
Asthma 68 99.50 Very High Very High Very High
Rheumatoid Arthritis 3 98.36 Very High Very High Very High
INFLAMMATION 42 98.32 Very High Very High Very High
Rhinitis 16 97.80 Very High Very High Very High
Arthropathy 1 97.64 Very High Very High Very High
Chondrocalcinosis 1 97.36 Very High Very High Very High
Adverse Drug Reaction 1 97.08 Very High Very High Very High
Cough 78 97.04 Very High Very High Very High
Osteoarthritis 1 96.60 Very High Very High Very High
Airway Obstruction 1 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Those with variant LTC4 synthase genotype (C/C or C/A genotype, n = 13) had a 9% increase in FEV1, whereas patients with the wild type (A/A genotype, n = 10) had a 12% decrease.[36] This polymorphism also shows an association with aspirin induced asthma and also contributes to increased LTC4 in the airway.[37] It is also considered as a potential risk factor for adverse reactions to nonsteroidal analgesics in asthma.
Positive_regulation (increased) of LTC4 associated with asthma, adverse drug reaction, aspirin and analgesic
1) Confidence 0.58 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.51 Pain Relevance 0.18
LTB4 was below the level of detection (< 1.5 ng/l) before and after cross-clamping in both groups, while the LTC4 level for group A increased from < 1.5 to 27 +/- 17 ng/l compared to an increase of < 1.5 to 11 +/- 8 ng/l for group B after 10 min of reperfusion (p = .036).
Positive_regulation (increased) of LTC4
2) Confidence 0.41 Published 1995 Journal Free Radic. Biol. Med. Section Abstract Doc Link 7649495 Disease Relevance 0.21 Pain Relevance 0.15
Calcium ionophore A23187 significantly increased the release of PGE2, 6-keto-PGF1 alpha, LTB4, and LTC4 from human synovial tissue irrespective of the underlying joint disease.
Positive_regulation (increased) of LTC4 in joint associated with arthropathy
3) Confidence 0.34 Published 1991 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 1673814 Disease Relevance 0.51 Pain Relevance 0.19
While concentrations of LTC4/D4/E4, were significantly higher in CRS-NP compared to CRS and controls, no differences were observed in LTB4 levels between the groups.
Positive_regulation (concentrations) of LTC4
4) Confidence 0.08 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.37 Pain Relevance 0.10
For example, many stimuli that produce robust activation of RARs (e.g. thromboxane, leukotriene C4 (LTC4), histamine, neurokinins, methacholine) are ineffective or only modestly effective at evoking cough [17,28,40-42].
Positive_regulation (activation) of LTC4 associated with cough
5) Confidence 0.01 Published 2005 Journal Cough Section Body Doc Link PMC1266044 Disease Relevance 0.66 Pain Relevance 0.27

General Comments

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