INT135436

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 31
Total Number 33
Disease Relevance 14.75
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa9) protein folding (Hspa9) mitochondrion (Hspa9)
enzyme binding (Hspa9) response to stress (Hspa9) cytoplasm (Hspa9)
Anatomy Link Frequency
muscle 4
skeletal muscles 1
muscle fibers 1
brainstem 1
spleen 1
Hspa9 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 272 99.98 Very High Very High Very High
methotrexate 280 99.92 Very High Very High Very High
Inflammation 710 99.42 Very High Very High Very High
medulla 32 98.50 Very High Very High Very High
Inflammatory stimuli 39 97.24 Very High Very High Very High
Spinal cord 147 96.52 Very High Very High Very High
Pain 125 95.40 Very High Very High Very High
substance P 63 89.00 High High
bradykinin 42 88.08 High High
chemokine 13 76.00 Quite High
Disease Link Frequency Relevance Heat
Shock 9 100.00 Very High Very High Very High
Myositis 546 99.64 Very High Very High Very High
Stress 388 99.18 Very High Very High Very High
INFLAMMATION 648 99.02 Very High Very High Very High
Cancer 95 98.60 Very High Very High Very High
Targeted Disruption 22 97.52 Very High Very High Very High
Muscle Disease 13 96.32 Very High Very High Very High
Chronic Disease 7 96.04 Very High Very High Very High
Severe Combined Immunodeficiency 10 95.24 Very High Very High Very High
Necrosis 45 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was therefore to investigate the stress-response ongoing in muscle fibers of patients affected with inflammatory myopathies, focusing on Grp94, calreticulin and Grp75 expression and distribution.
Gene_expression (expression) of Grp75 in muscle fibers associated with stress and inflammation
1) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.60 Pain Relevance 0.12
Conversely, Grp75 expression in myofibers of human and rat skeletal muscles appears related to oxidative stress occurring either during training of both high and low intensity [17] or during disuse [18].
Gene_expression (expression) of Grp75 in skeletal muscles associated with stress
2) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.46 Pain Relevance 0.04
Different patterns of immunohistochemical labeling for Grp94, Grp75 and calreticulin were detected in biopsies from the patient groups (Figures 1 and 2).
Gene_expression (detected) of Grp75
3) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.34 Pain Relevance 0
In fact, Grp75 was not detectable in regenerating myofibers, despite their higher expression of MHC-I (present manuscript and [33]).
Neg (not) Gene_expression (detectable) of Grp75
4) Confidence 0.62 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.90 Pain Relevance 0.10
Grp75 is an Hsp70 analog, mostly localized within ER and mitochondria [9]; in the present study, however, the increase in Grp75 immunoreactivity involved glycolytic fibers too, and its expression could therefore not be simply related to fiber mitochondrial content.
Gene_expression (expression) of Grp75
5) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.97 Pain Relevance 0.15
At variance with Grp94, Grp75 protein levels increased significantly in myositis biopsies with negligible levels of regeneration, and especially in those displaying a restricted sarcolemmal MHC-I immunoreactivity to a few clusters of myofibers [40].
Gene_expression (levels) of Grp75 protein associated with myositis
6) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.79 Pain Relevance 0.05
Previously, S-(1,1,2,2-tetrafluoroethyl)-l-cysteine (TFEC) was shown to mediate cytotoxicity by covalently modifying a well-defined group of intramitochondrial proteins including aconitase, alpha-ketoglutarate dehydrogenase (alphaKGDH) subunits, heat shock protein 60 (HSP60) and mitochondrial HSP70 (mtHSP70).
Gene_expression (group) of mtHSP70 associated with shock
7) Confidence 0.52 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16678137 Disease Relevance 0.17 Pain Relevance 0.08
These results indicate that, in myositis patients, muscle regeneration and inflammation, in addition to MHC-I upregulation, do evoke an ER stress-response characterized by the increased expression of Grp94 and Grp75, respectively.
Gene_expression (expression) of Grp75 in muscle associated with stress, inflammation and myositis
8) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.72 Pain Relevance 0.16
This feature might affect the correct evaluation of the basal level of ER chaperone expression; the slightly higher values of Grp75 levels detected in Group 0 patients compared with those of Group III patients, however, would add even more relevance to the findings concerning patients of Groups I and II.


Gene_expression (detected) of Grp75
9) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.95 Pain Relevance 0.11
Experimental systemic inflammation achieved in mice and rabbits by a single injection of bacterial lipopolysaccharide significantly increased Grp75 and calreticulin but not MHC-I expression in muscles.


Gene_expression (expression) of Grp75 in muscles associated with inflammation
10) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.79 Pain Relevance 0.19
Our study shows that a large proportion of our myositis patients displayed the presence of a multiple ER stress-response in myofibers, characterized by the differential expression of the ER chaperones Grp94 and Grp75.
Gene_expression (expression) of Grp75 associated with stress and myositis
11) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.87 Pain Relevance 0.12
The present study was undertaken to characterize in more detail the ER stress-response occurring in myofibers of patients with inflammatory myopathies, focusing on the expression and distribution of Grp94, calreticulin and Grp75, three ER chaperones involved in immunomodulation.


Gene_expression (expression) of Grp75 associated with stress and inflammation
12) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.83 Pain Relevance 0.16
Our data show that the two types of ER stress-response detectable in the presence of autoimmune myositis reveal the presence and the degree of muscle regeneration, by means of increased Grp94 levels, and reveal the influence of systemic stressing stimuli, probably of inflammatory origin, which are responsible for the increased expression of Grp75.
Gene_expression (expression) of Grp75 in muscle associated with stress, inflammation and myositis
13) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.90 Pain Relevance 0.11
Conversely, levels of calreticulin and Grp75 increased about fourfold and twofold, respectively, in patient biopsies positive for sarcolemmal MHC-I immunoreactivity, compared with healthy subjects and patients negative for both inflammation and MHC-I labeling (P < 0.005).
Gene_expression (levels) of Grp75 associated with inflammation
14) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.82 Pain Relevance 0.19
Previously, S-(1,1,2,2-tetrafluoroethyl)-l-cysteine (TFEC) was shown to mediate cytotoxicity by covalently modifying a well-defined group of intramitochondrial proteins including aconitase, alpha-ketoglutarate dehydrogenase (alphaKGDH) subunits, heat shock protein 60 (HSP60) and mitochondrial HSP70 (mtHSP70).
Gene_expression (group) of mitochondrial HSP70 associated with shock
15) Confidence 0.46 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16678137 Disease Relevance 0.17 Pain Relevance 0.08
Although involved QFM CSA decreased by approximately 10% postoperatively in both groups, it was only significant in the NMES group (p < 0.05).
Gene_expression (involved) of CSA
16) Confidence 0.43 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896350 Disease Relevance 0 Pain Relevance 0
A Gyroscan Intera 1.5 T MRI scanner (Philips Medical Systems, Holland) was used to determined QFM CSA of both thighs using a 4 mm slice thickness: 0.4 mm slice gap, 100 ms echo time; and 3000 ms relaxation time.
Spec (determined) Gene_expression (determined) of CSA in thighs
17) Confidence 0.43 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896350 Disease Relevance 0 Pain Relevance 0
Quadriceps femoris muscle strength and CSA
Gene_expression (strength) of CSA in muscle
18) Confidence 0.43 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896350 Disease Relevance 0 Pain Relevance 0
factors synthesized by RAE and CsA treated in BALF such as IgE were decreased

(Figure 7).

Gene_expression (synthesized) of CsA
19) Confidence 0.33 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.24 Pain Relevance 0.04
the lung cells treated with PBS only (NM), OVA (CT), CsA (10?
Gene_expression (treated) of CsA in lung
20) Confidence 0.29 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.25 Pain Relevance 0.06

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