INT135440

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.32
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Map2k1) Golgi apparatus (Map2k1) cytoplasm (Map2k1)
cell proliferation (Map2k1) cytosol (Map2k1) mitosis (Map2k1)
Anatomy Link Frequency
cerebral cortex 3
striatum 3
neurons 2
brain 2
Map2k1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 4 99.68 Very High Very High Very High
Morphine 24 99.54 Very High Very High Very High
withdrawal 17 99.52 Very High Very High Very High
narcan 8 98.84 Very High Very High Very High
Opioid 24 95.52 Very High Very High Very High
opioid receptor 4 94.56 High High
agonist 17 93.28 High High
Kappa opioid receptor 12 91.60 High High
addiction 8 77.32 Quite High
ischemia 15 74.96 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1 98.72 Very High Very High Very High
Opiate Addiction 20 95.52 Very High Very High Very High
Cv Unclassified Under Development 6 74.96 Quite High
Middle Cerebral Artery Infarction 27 69.72 Quite High
Brain Hemorrhage 5 50.00 Quite Low
Death 3 34.56 Quite Low
Injury 2 16.48 Low Low
Cv General 4 Under Development 10 6.72 Low Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sufentanil (1-30 microg/kg, 30-120 min) induced dose- and time-dependent increases in MEK1/2 phosphorylation in the cerebral cortex and corpus striatum (30-177%) through a naloxone-sensitive mechanism.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of MEK1 in cerebral cortex associated with narcan and cerebral cortex
1) Confidence 0.49 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16678156 Disease Relevance 0.25 Pain Relevance 1.19
In morphine-dependent rats, however, naloxone (2 mg/kg)-precipitated withdrawal (2-6 h) induced robust increases in MEK1/2 phosphorylation in cortex (27-49%) and striatum (83-123%).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of MEK1 in striatum associated with narcan, withdrawal and morphine
2) Confidence 0.49 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16678156 Disease Relevance 0.23 Pain Relevance 1.47
Morphine (100 mg/kg, 2 h) also augmented MEK1/2 phosphorylation in the both brain regions (50-70%).
Positive_regulation (augmented) of Phosphorylation (phosphorylation) of MEK1 in brain associated with morphine
3) Confidence 0.49 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16678156 Disease Relevance 0.23 Pain Relevance 1.30
Sufentanil (1-30 microg/kg, 30-120 min) induced dose- and time-dependent increases in MEK1/2 phosphorylation in the cerebral cortex and corpus striatum (30-177%) through a naloxone-sensitive mechanism.
Positive_regulation (increases) of in corpus striatum Phosphorylation (phosphorylation) of MEK1 in cerebral cortex associated with narcan and cerebral cortex
4) Confidence 0.17 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16678156 Disease Relevance 0.25 Pain Relevance 1.19
In addition, U0126 increases phosphorylation of MEK1/2 in cortical neurons; hence, U0126 does not affect upstream components of MEK1/2 [19].
Positive_regulation (increases) of Phosphorylation (phosphorylation) of MEK1 in neurons
5) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553085 Disease Relevance 0.36 Pain Relevance 0.07

General Comments

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