INT135444

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.15
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Map2k1) Golgi apparatus (Map2k1) cytoplasm (Map2k1)
cell proliferation (Map2k1) cytosol (Map2k1) mitosis (Map2k1)
Anatomy Link Frequency
brain 1
Map2k1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 6 99.52 Very High Very High Very High
withdrawal 4 99.14 Very High Very High Very High
Opioid 6 98.92 Very High Very High Very High
Kinase C 42 93.48 High High
narcan 2 91.64 High High
agonist 70 89.60 High High
addiction 4 84.32 Quite High
depression 2 79.84 Quite High
Kappa opioid receptor 3 78.20 Quite High
Inflammation 14 77.72 Quite High
Disease Link Frequency Relevance Heat
Stress 25 99.40 Very High Very High Very High
Opiate Addiction 5 99.14 Very High Very High Very High
Death 7 92.36 High High
Disease 7 85.84 High High
Chondrocalcinosis 12 80.80 Quite High
Depression 2 79.84 Quite High
INFLAMMATION 17 77.72 Quite High
Bacillus Anthracis Infection 28 75.00 Quite High
Pressure And Volume Under Development 14 52.48 Quite High
Cancer 4 48.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spontaneous opioid withdrawal (24 h) in morphine-dependent rats did not alter MEK1/2 activity in the brain.
Regulation (alter) of MEK1 in brain associated with withdrawal, opioid and morphine
1) Confidence 0.44 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16678156 Disease Relevance 0.23 Pain Relevance 1.37
Stress signaling cascades including MEK1/2, p38, ERK and JNK were unaffected by in vitro lethal toxins whereas they were significantly altered by in vivo lethal toxins.
Neg (unaffected) Regulation (unaffected) of MEK1 associated with stress
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954163 Disease Relevance 0.60 Pain Relevance 0.04
The suppressive effect of ATRA on the activation of activator protein-1 (AP-1) and nuclear factor-IL-6 (NF-IL-6) was reproduced by the MEK1 (mitogen-activated protein extracellularly regulated kinase kinase 1) inhibitor PD-98059, whereas ATRA and PD-98059 had no effect on NF-?
Regulation (regulated) of MEK1
3) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656246 Disease Relevance 0.08 Pain Relevance 0.22
APase = alkaline phosphatase; CPPD = calcium pyrophosphate dihydrate; Ct = threshold cycle; DMEM = Dulbecco's modified Eagle's medium; ePPi = extracellular inorganic pyrophosphate; ERK = extracellular signal-regulated kinase; FCS = fetal calf serum; iPPi = intracellular inorganic pyrophosphate; MAPK = mitogen-activated protein kinase; MEK-1 = mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1; NPPase = nucleotide pyrophosphatase phosphodiesterase; PBS = phosphate-buffered saline; PCR = polymerase chain reaction; PKA = protein kinase A; PKC = protein kinase C; p-NP = para-nitrophenol; p-NPP = para-nitrophenyl phosphate; p-NPTMP = para-nitrophenylthymidine 5'-monophosphate; PPi = inorganic pyrophosphate; siRNA = small interfering RNA; TBS = Tris-buffered saline; TGF-?
Regulation (regulated) of MEK-1 associated with kinase c
4) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.25 Pain Relevance 0.13

General Comments

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