INT135470

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Context Info
Confidence 0.63
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 12.04
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
Lungs 3
leukocyte 1
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 161 97.44 Very High Very High Very High
Inflammatory marker 3 97.22 Very High Very High Very High
anesthesia 13 90.88 High High
Angina 6 86.16 High High
ischemia 30 81.92 Quite High
cytokine 33 79.20 Quite High
Inflammatory mediators 16 69.76 Quite High
tolerance 1 65.52 Quite High
chemokine 10 65.04 Quite High
Sciatic nerve 17 53.12 Quite High
Disease Link Frequency Relevance Heat
Adhesions 46 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Cancer 7 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 7 99.64 Very High Very High Very High
Pressure Volume 2 Under Development 210 99.48 Very High Very High Very High
Inflammatory Bowel Disease 5 98.36 Very High Very High Very High
Stress 25 98.16 Very High Very High Very High
Acute Coronary Syndrome 7 97.68 Very High Very High Very High
Hypoxia 2 97.60 Very High Very High Very High
Apoptosis 32 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, in HYPO group after RM, the mRNA expression of VCAM-1 and ICAM-1 decreased, probably reflecting reduced shear stress.
Transcription (expression) of ICAM-1 associated with stress and pressure volume 2 under development
1) Confidence 0.63 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.21 Pain Relevance 0.16
In addition, RMs induced higher mRNA expression of VCAM-1 in NORMO and HYPER groups, but not of ICAM-1, which was presented higher in HYPER group regardless of RM.
Transcription (expression) of ICAM-1
2) Confidence 0.61 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.27 Pain Relevance 0.13
Finally, the effects of volemic status and RM on mRNA expressions of ICAM-1 and VCAM-1 were determined because these adhesion molecules are involved in the accumulation of neutrophils in the lung tissue, playing a crucial role in the pathogenesis of VILI [39].


Transcription (expressions) of ICAM-1 in lung associated with lung injury and adhesions
3) Confidence 0.61 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.27 Pain Relevance 0.03
A reduced TNF-alpha and ICAM-1 mRNA expression seen after IP may account for the inhibitory effects of IP on leukocyte adhesion and ameloriated microcirculatory disturbance after IR in vivo [23-26].
Transcription (expression) of ICAM-1 in leukocyte associated with adhesions
4) Confidence 0.52 Published 2006 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1636295 Disease Relevance 0.58 Pain Relevance 0.10
Lungs were excised 2 or 24 h after resuscitation, and mRNA levels of tumor necrosis factor alpha (TNF-alpha), intercellular adhesion molecule-1 (ICAM-1), nitric oxide synthase 2 (iNOS), nitric oxide synthase 3, hypoxia-inducible factor 1 alpha, and heme oxygenase 1 (HO-1) were measured.
Transcription (levels) of ICAM-1 in Lungs associated with necrosis, hypoxia, cancer and adhesions
5) Confidence 0.46 Published 2009 Journal ASAIO J. Section Abstract Doc Link 19625952 Disease Relevance 1.33 Pain Relevance 0.34
Lungs were excised 2 or 24 h after resuscitation, and mRNA levels of tumor necrosis factor alpha (TNF-alpha), intercellular adhesion molecule-1 (ICAM-1), nitric oxide synthase 2 (iNOS), nitric oxide synthase 3, hypoxia-inducible factor 1 alpha, and heme oxygenase 1 (HO-1) were measured.
Transcription (levels) of intercellular adhesion molecule-1 in Lungs associated with necrosis, hypoxia, cancer and adhesions
6) Confidence 0.46 Published 2009 Journal ASAIO J. Section Abstract Doc Link 19625952 Disease Relevance 1.33 Pain Relevance 0.34
Our data showed that the mRNA expression of ICAM-1 was significantly suppressed by curcumin in vitro and in vivo (Fig. 3B and C).
Transcription (expression) of ICAM
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 1.24 Pain Relevance 0.49
After up to 24 hours in culture, protein and mRNA expression of ICAM-1 was monitored using ELISA and real-time PCR, respectively.
Transcription (expression) of ICAM-1
8) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.51 Pain Relevance 0.11
The mRNA levels of ICAM-1 were also increased significantly compared to vehicle control cultures (Figure 4(b)).
Transcription (levels) of ICAM-1
9) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.46 Pain Relevance 0.11
Relative mRNA expression of ICAM-1, MCP-1, IL-6, and P-selectin was determined using predeveloped assays for real-time PCR (Applied Biosystems, Foster City, CA).
Spec (determined) Transcription (expression) of ICAM-1
10) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.18 Pain Relevance 0.06
Overall, the level of serum inflammatory markers was highest in the ACS group and lowest in the control group, with intermediate values observed in the SAP and vasospasm groups, with the exception of soluble intercellular adhesion molecule-1, the level of which was highest in the vasospasm group.
Neg (exception) Transcription (exception) of intercellular adhesion molecule-1 associated with acute coronary syndrome, inflammatory marker, increased venous pressure under development and adhesions
11) Confidence 0.13 Published 2006 Journal Am. J. Cardiol. Section Abstract Doc Link 16679078 Disease Relevance 2.65 Pain Relevance 0.56

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