INT135473

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 5.47
Pain Relevance 5.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
Amygdala 4
ACSF 2
brains 2
nucleus 2
hippocampus 2
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 72 100.00 Very High Very High Very High
amygdala 34 100.00 Very High Very High Very High
Neurotransmitter 11 100.00 Very High Very High Very High
narcan 6 99.96 Very High Very High Very High
Dorsal horn 9 99.84 Very High Very High Very High
Morphine 5 98.08 Very High Very High Very High
withdrawal 21 97.44 Very High Very High Very High
long-term potentiation 102 97.40 Very High Very High Very High
Enkephalin 3 95.44 Very High Very High Very High
projection neuron 1 94.84 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 326 99.64 Very High Very High Very High
Autoimmune Disease 9 99.40 Very High Very High Very High
Anxiety Disorder 51 99.12 Very High Very High Very High
Systemic Lupus Erythematosus 66 97.28 Very High Very High Very High
Toxicity 1 97.12 Very High Very High Very High
Meningitis 19 96.60 Very High Very High Very High
Schizophrenia 26 95.40 Very High Very High Very High
Congenital Anomalies 20 94.24 High High
Opiate Addiction 10 91.76 High High
Myelodysplastic Syndromes 1 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amygdala microinjection of rAAV-GFP-Cre produced a decrease in NR1 gene expression and protein immunolabeling in postsynaptic sites of neurons without signs of compromised ultrastructural neuronal morphology.
Negative_regulation (decrease) of Gene_expression (expression) of NR1 gene in Amygdala associated with amygdala
1) Confidence 0.47 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18614169 Disease Relevance 0.38 Pain Relevance 1.25
The vector-derived knockdown of NR1 expression in SCDH did not alter acute thermal or mechanical stimulus paw-withdrawal thresholds.
Negative_regulation (knockdown) of Gene_expression (expression) of NR1 in paw associated with dorsal horn and withdrawal
2) Confidence 0.40 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17551091 Disease Relevance 0.46 Pain Relevance 0.83
The decrease in expression was not associated with any significant change in expression of NR1 or NR2B.
Negative_regulation (decrease) of Gene_expression (expression) of NR1
3) Confidence 0.35 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.34 Pain Relevance 0.52
In the region of the cortical injection site, NR1 mRNA levels were markedly reduced, suggesting that the lentivector injection had indeed induced a local NR1 KO (n?
Negative_regulation (reduced) of Gene_expression (levels) of NR1 mRNA associated with targeted disruption
4) Confidence 0.34 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.23 Pain Relevance 0
Preliminary data in primary cultured neurons showed three of these resulted in partial knockdown of NR1 protein expression assayed by western blotting.
Spec (partial) Negative_regulation (knockdown) of Gene_expression (expression) of NR1 in neurons
5) Confidence 0.34 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.15 Pain Relevance 0.03
Conditional deletion of the NMDA-NR1 receptor subunit gene in the central nucleus of the amygdala inhibits naloxone-induced conditioned place aversion in morphine-dependent mice.
Negative_regulation (inhibits) of Gene_expression (deletion) of NMDA-NR1 receptor subunit gene in nucleus associated with narcan, amygdala and morphine
6) Confidence 0.30 Published 2008 Journal Exp. Neurol. Section Title Doc Link 18614169 Disease Relevance 0.24 Pain Relevance 1.00
m were cut from brains of injected fNR1 animals, frozen on crushed dry ice after perfusion with 4% PFA, a 90?
Negative_regulation (injected) of Gene_expression (animals) of fNR1 in brains
7) Confidence 0.30 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0.22 Pain Relevance 0.03
Thus, the morphological changes observed in dendritic spines may have been a result of the observed decreases in the expression of the NR1, PSD-95, p-CaMKII, and PAK families.
Negative_regulation (decreases) of Gene_expression (expression) of NR1 in spines
8) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.60 Pain Relevance 0.19
The KO mice also showed decreased expression of the NR1, PSD-95, p-CaMKII, and PAK families, and these signaling pathways are known to regulate synaptic structure and function in the developing cortex [43], [44], [45].
Negative_regulation (decreased) of Gene_expression (expression) of NR1 in cortex associated with targeted disruption
9) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.66 Pain Relevance 0.24
The NMDAR-mediated component of mEPSCs was pharmacologically isolated in ACSF containing CNQX (20 ?
Negative_regulation (isolated) of Gene_expression (component) of NMDAR-mediated in ACSF
10) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.32 Pain Relevance 0.08
Consequently, a potential mechanism for NMDAR-independent learning and plasticity in the hippocampus is the expression and activation of GluR2-lacking (Ca2+-permeable) AMPARs.
Negative_regulation (lacking) of Gene_expression (expression) of NMDAR in hippocampus associated with hippocampus
11) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.06 Pain Relevance 0.35
Western blots show a reduction in phosphorylated-NR1, NR2A, and NR2B subunit protein expression in the amygdala from fear-conditioned animals.
Negative_regulation (reduction) of Gene_expression (expression) of NR1 in amygdala associated with anxiety disorder and amygdala
12) Confidence 0.17 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.77 Pain Relevance 0.68
The amount of postsynaptic neurotransmitter receptor protein, such as NMDAR or GlyR, was not reduced (Table 1), which argues against a possible lack of postsynaptic sensitivity.
Neg (not) Negative_regulation (reduced) of Gene_expression (amount) of NMDAR associated with neurotransmitter
13) Confidence 0.11 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.13
G/Gsat: 5.93%±0.38% and 5.80%±0.44%, respectively) that are predicted by the linear sums of the NMDAR-only and AMPAR-only uEPSP and ?
Negative_regulation (predicted) of Gene_expression (sums) of NMDAR-only
14) Confidence 0.08 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2734993 Disease Relevance 0 Pain Relevance 0.04
Antinuclear, anti-dsDNA, anti-ribosomal P, Anti-N-Methyl-D-Aspartate receptor (NMDAR), anti-cardiolipin, and anti-?
Negative_regulation (anti-ribosomal P) of Gene_expression (anti-dsDNA) of Anti-N-Methyl-D-Aspartate receptor
15) Confidence 0.04 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2556096 Disease Relevance 1.05 Pain Relevance 0

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