INT135511

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MRGPRX4) signal transducer activity (MRGPRX4)
Anatomy Link Frequency
adrenal medulla 2
MRGPRX4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 100.00 Very High Very High Very High
medulla 4 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
antagonist 2 99.36 Very High Very High Very High
Pain 2 86.84 High High
Enkephalin 2 85.60 High High
Disease Link Frequency Relevance Heat
Pain 2 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the deltaOR selective antagonist naltrexone trans-inhibited the SNSR-4-promoted phospholipase C activation mediated by BAM22 but not by the SNSR-4-selective agonists, suggesting a bivalent binding mode of BAM22 to the deltaOR/SNSR-4 hetero-oligomer.
Neg (not) Positive_regulation (mediated) of Positive_regulation (activation) of SNSR-4-promoted associated with antagonist and agonist
1) Confidence 0.16 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682504 Disease Relevance 0 Pain Relevance 0.43
Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling.
Positive_regulation (activates) of Positive_regulation (activation) of SNSR-4 in adrenal medulla associated with medulla, agonist and opioid receptor
2) Confidence 0.16 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16682504 Disease Relevance 0.09 Pain Relevance 0.36

General Comments

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