INT135540

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 11.80
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
neuronal 1
precursor cells 1
nervous system 1
kidney 1
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 6 99.88 Very High Very High Very High
allodynia 1 99.38 Very High Very High Very High
Thermal hyperalgesia 1 98.88 Very High Very High Very High
Inflammatory mediators 3 93.24 High High
depression 1 90.20 High High
Spinal cord 7 89.36 High High
Sciatic nerve 3 87.76 High High
Arthritis 64 87.32 High High
Inflammation 87 86.92 High High
Dorsal horn 2 84.96 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 450 100.00 Very High Very High Very High
Injury 181 99.88 Very High Very High Very High
Colon Cancer 9 99.86 Very High Very High Very High
Aging 5 99.64 Very High Very High Very High
Neuropathic Pain 5 99.38 Very High Very High Very High
Malignant Neoplastic Disease 17 99.34 Very High Very High Very High
Stress 83 99.20 Very High Very High Very High
Huntington's Chorea 1 99.00 Very High Very High Very High
Hyperalgesia 1 98.88 Very High Very High Very High
Adenoma 2 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting showed that a single injection of naltrexone (1 mg/kg) induced a down-regulation of the pro-apototic proteins Fas, FasL, Bad and Bax.
Negative_regulation (down-regulation) of Bax
1) Confidence 0.48 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.24 Pain Relevance 0.27
Human colorectal cancer cells lacking a functional BAX gene, HCT116BAX-/- [20], were a gift from Dr.
Negative_regulation (lacking) of BAX gene associated with colon cancer
2) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.16 Pain Relevance 0
Administration of phenyl-N-tert-butylnitrone (PBN), a potent ROS scavenger, reduced the development of thermal hyperalgesia and mechanical allodynia at 1 and 3 days post-CCI, and decreased the mRNA levels of bax, apaf-1, and caspase-9.
Negative_regulation (decreased) of bax associated with allodynia, eae and thermal hyperalgesia
3) Confidence 0.42 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17207636 Disease Relevance 1.42 Pain Relevance 1.14
In addition, various neuronal cell-types, which rely solely on BAX for pro-apoptotic activity, become highly resistant to lesions of the nervous system when their BAX levels are reduced [15-18].
Negative_regulation (reduced) of BAX in nervous system associated with apoptosis
4) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 1.16 Pain Relevance 0.04
Normally, CR functions to decrease oxidative stress by inhibiting apoptosis [62] through a reduction in Bax (in the aging mouse heart) [82] and elevation in Bcl-2 (in the aging rat kidney) [83].
Negative_regulation (reduction) of Bax in kidney associated with stress, aging and apoptosis
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.13 Pain Relevance 0.07
Similar techniques have also been used to discern a temporal relationship between target genes in the progression from adenoma to full blown malignancy emphasizing the likelihood that loss of BAX, TGF?
Negative_regulation (loss) of BAX associated with adenoma and malignant neoplastic disease
6) Confidence 0.25 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.49 Pain Relevance 0
A decrease in p53 dependent transcription, and in levels of Bax, which is regulated by p53 [30], was observed in COS cells expressing Hr.
Negative_regulation (decrease) of Bax
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.16 Pain Relevance 0
Justicidin A also reduced Bcl-x(L) and increased Bax and Bak in mitochondria.
Negative_regulation (reduced) of Bax
8) Confidence 0.21 Published 2006 Journal FEBS Lett. Section Abstract Doc Link 16684533 Disease Relevance 0.67 Pain Relevance 0.08
AS Bcl-2-mediated downregulation of Bcl-2 augments anticancer drug-induced signal transduction pathways leading to apoptosis, which is associated with the activation of proapoptotic proteins such as Bax and the suppression of antiapoptotic proteins such as Bcl-2 and pAkt.
Negative_regulation (suppression) of Bax associated with apoptosis
9) Confidence 0.18 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.86 Pain Relevance 0
Indeed, several reports have demonstrated that lithium, in neuronal cell models and in vivo, has neuroprotective activity via the up regulation of antiapoptotic and reduction of proapoptotic Bcl-2 family proteins, including Bcl-2 and Bax [21], [62]–[65].
Negative_regulation (reduction) of Bax in neuronal
10) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.81 Pain Relevance 0.05
Although the ratio of Bax/Bcl-2 at 48 h time point was decreased in some degree than 24 h time point, it was still far higher than that of control (Fig 5).
Negative_regulation (decreased) of Bax
11) Confidence 0.16 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.71 Pain Relevance 0
 ; constitutive expression of COX-2, which produces prostaglandins that may recruit GSM precursor cells to the injured pit region [53]; and upregulation of anti-apoptotic proteins such as HSP70 and Bcl-2, downregulation of pro-apoptotic Bax, and inhibition of pro-caspase 3 activation.
Negative_regulation (downregulation) of Bax in precursor cells associated with apoptosis
12) Confidence 0.15 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.74 Pain Relevance 0
Moreover, it was already reported that tacrolimus prevented an increase in the Bax/Bcl-2 ratio following an apoptotic stimulus in U251 cells, while others found a reduction in mitochondrial Bax with the overall expression level remaining unchanged [19,20].
Negative_regulation (reduction) of Bax associated with apoptosis
13) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1386691 Disease Relevance 0.53 Pain Relevance 0
Taken together with the previous reports that BHRF1 interacts with the full-length Bak, but not with Bax [17], [31], [32], we conclude that BHRF1 can keep Bak inactive by direct binding (Fig. 3A, 3C, [19]), but must inhibit Bax indirectly, presumably by its ability to sequester BH3-only proteins such as Bim (Fig. 3A, 3B, [31]).
Negative_regulation (inhibit) of Bax
14) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009601 Disease Relevance 0.56 Pain Relevance 0
Interestingly, a deficiency in the proapoptosis gene, Bax, also partially corrected IL-7R?
Negative_regulation (deficiency) of Bax
15) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.27 Pain Relevance 0.12
CO also significantly reduced mRNA for proapoptotic Bax, while it up-regulated anti-apoptotic Bcl-2.
Negative_regulation (reduced) of Bax associated with apoptosis
16) Confidence 0.08 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266059 Disease Relevance 0.89 Pain Relevance 0.12

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