INT135541

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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.52
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bak1) cytosol (Bak1) mitochondrion (Bak1)
endoplasmic reticulum (Bak1) intracellular (Bak1)
Anatomy Link Frequency
A549 1
Bak1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 7 91.48 High High
Inflammation 6 91.00 High High
Pain 3 84.40 Quite High
antagonist 4 79.60 Quite High
Inflammatory marker 2 33.28 Quite Low
positron emission tomography 8 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 20 100.00 Very High Very High Very High
Apoptosis 90 98.52 Very High Very High Very High
Toxicity 6 93.12 High High
Shock 5 93.12 High High
INFLAMMATION 10 91.00 High High
Hepatocellular Cancer 2 90.64 High High
Death 31 89.84 High High
Cancer 61 89.40 High High
Severe Combined Immunodeficiency 1 88.40 High High
Injury 1 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unfortunately, few data are available that evaluate the clinical benefit of eliminating BAK from prostaglandin analog therapy.
Negative_regulation (eliminating) of BAK
1) Confidence 0.30 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2694010 Disease Relevance 0.76 Pain Relevance 0
However, both groups experienced a significant decrease in hyperemia with travoprost BAK-free (0.5 ± 0.6 and 0.6 ± 0.7, respectively; p < 0.0001).
Negative_regulation (decrease) of BAK associated with increased venous pressure under development
2) Confidence 0.30 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2694010 Disease Relevance 0.92 Pain Relevance 0
Stimulation of apoptosis in lapatinib-treated A549 cells was correlated with increased cleaved PARP, active caspase-3, and proapoptotic Bak-1 levels, and reduction in the antiapoptic IAP-2 and Bcl-xL protein levels.
Negative_regulation (reduction) of Bak in A549 associated with apoptosis
3) Confidence 0.27 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2883966 Disease Relevance 0.88 Pain Relevance 0
Justicidin A also reduced Bcl-x(L) and increased Bax and Bak in mitochondria.
Negative_regulation (reduced) of Bak
4) Confidence 0.23 Published 2006 Journal FEBS Lett. Section Abstract Doc Link 16684533 Disease Relevance 0.67 Pain Relevance 0.08
Cells from mice deficient for both Bax and Bak, but not cells deficient for one or the other only, are almost completely resistant to mitochondria-mediated apoptosis [37], suggesting that these proteins have redundant functions in this pathway.
Negative_regulation (deficient) of Bak associated with apoptosis
5) Confidence 0.05 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.70 Pain Relevance 0.16
Lansoprazole prevents indomethacin-induced up-regulation of proapoptotic Bax and Bak and down-regulation of antiapoptotic Bcl-2 and Bcl(xL) to maintain the normal proapoptotic/antiapoptotic ratio and thereby arrests indomethacin-induced mitochondrial translocation of Bax and collapse of mitochondrial membrane potential followed by cytochrome c release and caspase-9 activation.
Negative_regulation (down-regulation) of Bak associated with shock
6) Confidence 0.04 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18375387 Disease Relevance 0.59 Pain Relevance 0.25

General Comments

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