INT135551

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 6.71
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FASLG) extracellular space (FASLG) extracellular region (FASLG)
plasma membrane (FASLG) cell-cell signaling (FASLG)
Anatomy Link Frequency
knee joints 4
articular 2
neutrophil 2
FASLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 95 99.78 Very High Very High Very High
rheumatoid arthritis 85 86.72 High High
Pain 5 85.88 High High
cytokine 5 76.80 Quite High
cINOD 2 74.84 Quite High
Arthritis 50 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 96 99.78 Very High Very High Very High
Arthritis 125 99.14 Very High Very High Very High
Apoptosis 337 98.84 Very High Very High Very High
Leukocytosis 10 96.24 Very High Very High Very High
Infection 15 90.80 High High
Lung Cancer 2 90.16 High High
Rheumatoid Arthritis 85 86.72 High High
Pain 5 85.88 High High
Death 45 81.80 Quite High
Cancer 41 76.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, combination treatment with As2O3 and sulindac increased the catalytic activity of caspase-3, -8, and -9 along with induction of Fas/FasL expression and cytosolic release of cytochrome c.
Positive_regulation (induction) of Gene_expression (expression) of FasL
1) Confidence 0.67 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685442 Disease Relevance 0.56 Pain Relevance 0.15
The extent of apoptosis observed was similar to that observed following adenoviral gene transfer of TRAIL and FasL.


Positive_regulation (transfer) of Gene_expression (transfer) of FasL associated with apoptosis
2) Confidence 0.33 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.91 Pain Relevance 0.05
The one exception was with adenoviral gene transfer of FasL, which resulted in synovial apoptosis but also an increase in neutrophil infiltration.
Positive_regulation (transfer) of Gene_expression (transfer) of FasL in neutrophil associated with apoptosis
3) Confidence 0.33 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.43 Pain Relevance 0.18
In addition, intra-articular injection of the adenoviral (Ad)-TRAIL vector resulted in extensive apoptosis, similar to that observed with FasL, but was able to reduce joint inflammation in contrast to the inflammatory effect of FasL gene transfer.
Positive_regulation (transfer) of Gene_expression (transfer) of FasL in articular associated with inflammation, apoptosis and arthritis
4) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.23 Pain Relevance 0.23
Previously, we have shown that adenoviral mediated gene transfer of p53 [10] and FasL [11] to inflamed rabbit knee joints results in induction of significant synovial apoptosis as well as reduction of the extent of leukocytic infiltration.
Positive_regulation (mediated) of Gene_expression (transfer) of FasL in knee joints associated with apoptosis
5) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.30 Pain Relevance 0.32
Previously, we have shown that adenoviral mediated gene transfer of p53 [10] and FasL [11] to inflamed rabbit knee joints results in induction of significant synovial apoptosis as well as reduction of the extent of leukocytic infiltration.
Positive_regulation (transfer) of Gene_expression (transfer) of FasL in knee joints associated with apoptosis
6) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.29 Pain Relevance 0.32

General Comments

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