INT135558

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2008
Negated 1
Speculated 6
Reported most in Abstract
Documents 10
Total Number 23
Disease Relevance 17.13
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ogfr) cytoplasm (Ogfr)
Anatomy Link Frequency
neck 15
head 5
MIA PaCa-2 4
Ogfr (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 51 100.00 Very High Very High Very High
Enkephalin 5 80.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 217 100.00 Very High Very High Very High
Skin Cancer 34 99.80 Very High Very High Very High
Pancreatic Cancer 18 99.80 Very High Very High Very High
Squamous Cell Neoplasms 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prevention and delay in progression of human squamous cell carcinoma of the head and neck in nude mice by stable overexpression of the opioid growth factor receptor.
Positive_regulation (overexpression) of Gene_expression (overexpression) of opioid growth factor receptor in neck associated with skin cancer and opioid
1) Confidence 0.70 Published 2008 Journal Int. J. Oncol. Section Title Doc Link 18813788 Disease Relevance 0.84 Pain Relevance 0.20
This study examined overexpression of the opioid growth factor receptor (OGFr) in squamous cell carcinoma of the head and neck and phenotypic repercussions on tumorigenicity.
Spec (examined) Positive_regulation (overexpression) of Spec (examined) Gene_expression (overexpression) of opioid growth factor receptor in neck associated with skin cancer and opioid
2) Confidence 0.70 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18813788 Disease Relevance 0.51 Pain Relevance 0.17
Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor.
Positive_regulation (overexpression) of Gene_expression (overexpression) of opioid growth factor receptor associated with pancreatic cancer and opioid
3) Confidence 0.70 Published 2008 Journal Int. J. Oncol. Section Title Doc Link 18636152 Disease Relevance 0.78 Pain Relevance 0.20
This study examined overexpression of the opioid growth factor receptor (OGFr) in pancreatic cancer cells and phenotypic changes in tumorigenicity.
Spec (examined) Positive_regulation (overexpression) of Spec (examined) Gene_expression (overexpression) of opioid growth factor receptor associated with pancreatic cancer and opioid
4) Confidence 0.70 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18636152 Disease Relevance 0.68 Pain Relevance 0.17
Tumor weight of all animals overexpressing OGFr were 48-67% of EV mice, and the number of cells undergoing DNA synthesis in these tumors with amplified OGFr was reduced 46-65% of the EV group.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of OGFr associated with cancer
5) Confidence 0.61 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18813788 Disease Relevance 0.99 Pain Relevance 0.14
Tumors from 3 SCC-1 cell lines (OGFr-9, OGFr-18, OGFr-22) stably transfected with OGFr cDNA (OGFr-1) had 2.5- to 3.7-fold more OGFr than empty vector (EV) or wild-type (WT) neoplasias.
Positive_regulation (transfected) of Gene_expression (transfected) of OGFr-1 associated with cancer
6) Confidence 0.61 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18813788 Disease Relevance 0.64 Pain Relevance 0.17
Latency times for OGFr-1 tumor expression were increased 30%, tumor volume was decreased 70%, and DNA synthesis was reduced 24% relative to EV mice.
Positive_regulation (increased) of Gene_expression (expression) of OGFr-1 associated with cancer
7) Confidence 0.61 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18636152 Disease Relevance 0.82 Pain Relevance 0.16
Tumors from 3 SCC-1 cell lines (OGFr-9, OGFr-18, OGFr-22) stably transfected with OGFr cDNA (OGFr-1) had 2.5- to 3.7-fold more OGFr than empty vector (EV) or wild-type (WT) neoplasias.
Positive_regulation (transfected) of Gene_expression (transfected) of OGFr-18 associated with cancer
8) Confidence 0.50 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18813788 Disease Relevance 0.64 Pain Relevance 0.17
This study examined overexpression of the opioid growth factor receptor (OGFr) in squamous cell carcinoma of the head and neck and phenotypic repercussions on tumorigenicity.
Spec (examined) Positive_regulation (overexpression) of Spec (examined) Gene_expression (overexpression) of OGFr in neck associated with skin cancer and opioid
9) Confidence 0.50 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18813788 Disease Relevance 0.52 Pain Relevance 0.17
Tumors from 3 SCC-1 cell lines (OGFr-9, OGFr-18, OGFr-22) stably transfected with OGFr cDNA (OGFr-1) had 2.5- to 3.7-fold more OGFr than empty vector (EV) or wild-type (WT) neoplasias.
Positive_regulation (transfected) of Gene_expression (transfected) of OGFr-22 associated with cancer
10) Confidence 0.50 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18813788 Disease Relevance 0.64 Pain Relevance 0.17
Tumors from 3 SCC-1 cell lines (OGFr-9, OGFr-18, OGFr-22) stably transfected with OGFr cDNA (OGFr-1) had 2.5- to 3.7-fold more OGFr than empty vector (EV) or wild-type (WT) neoplasias.
Positive_regulation (transfected) of Gene_expression (transfected) of OGFr-9 associated with cancer
11) Confidence 0.50 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18813788 Disease Relevance 0.64 Pain Relevance 0.17
This study examined overexpression of the opioid growth factor receptor (OGFr) in pancreatic cancer cells and phenotypic changes in tumorigenicity.
Spec (examined) Positive_regulation (overexpression) of Spec (examined) Gene_expression (overexpression) of OGFr associated with pancreatic cancer and opioid
12) Confidence 0.50 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18636152 Disease Relevance 0.68 Pain Relevance 0.17
Receptor affinity and the gene expression of OGFr mRNA were unchanged in tumors of different sizes.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of OGFr mRNA associated with cancer
13) Confidence 0.50 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685459 Disease Relevance 0.97 Pain Relevance 0.24
To inquire whether the expression of OGFr is related to tumor progression, cell lines of human squamous cell carcinoma of the head and neck (SCCHN) were transplanted into nude mice, and small, medium, and large tumors were assessed for OGFr by receptor binding assays and quantitative immunohistochemistry, and for gene expression of OGFr mRNA.
Positive_regulation (assessed) of Gene_expression (expression) of OGFr mRNA in neck associated with cancer and skin cancer
14) Confidence 0.50 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685459 Disease Relevance 0.95 Pain Relevance 0.31
Tumors from 3 SCC-1 cell lines (OGFr-9, OGFr-18, OGFr-22) stably transfected with OGFr cDNA (OGFr-1) had 2.5- to 3.7-fold more OGFr than empty vector (EV) or wild-type (WT) neoplasias.
Positive_regulation (transfected) of Gene_expression (transfected) of OGFr associated with cancer
15) Confidence 0.44 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18813788 Disease Relevance 0.64 Pain Relevance 0.17
Tumors of MIA PaCa-2 cells transfected with OGFr cDNA (OGFr-1) had 3.3 times more OGFr than empty vector (EV) neoplasias, and 4.3 times more OGFr than tumors from wild-type (WT) mice.
Positive_regulation (transfected) of Gene_expression (transfected) of OGFr-1 in MIA PaCa-2 associated with cancer
16) Confidence 0.44 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18636152 Disease Relevance 0.75 Pain Relevance 0.17
Tumors of MIA PaCa-2 cells transfected with OGFr cDNA (OGFr-1) had 3.3 times more OGFr than empty vector (EV) neoplasias, and 4.3 times more OGFr than tumors from wild-type (WT) mice.
Positive_regulation (transfected) of Gene_expression (transfected) of OGFr in MIA PaCa-2 associated with cancer
17) Confidence 0.44 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18636152 Disease Relevance 0.74 Pain Relevance 0.17
To inquire whether the expression of OGFr is related to tumor progression, cell lines of human squamous cell carcinoma of the head and neck (SCCHN) were transplanted into nude mice, and small, medium, and large tumors were assessed for OGFr by receptor binding assays and quantitative immunohistochemistry, and for gene expression of OGFr mRNA.
Positive_regulation (assessed) of Gene_expression (expression) of OGFr in neck associated with cancer and skin cancer
18) Confidence 0.44 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685459 Disease Relevance 0.94 Pain Relevance 0.31
This study examined overexpression of the opioid growth factor receptor (OGFr) in squamous cell carcinoma of the head and neck and phenotypic repercussions on tumorigenicity.
Spec (examined) Positive_regulation (overexpression) of in head Spec (examined) Gene_expression (overexpression) of opioid growth factor receptor in neck associated with skin cancer and opioid
19) Confidence 0.24 Published 2008 Journal Int. J. Oncol. Section Abstract Doc Link 18813788 Disease Relevance 0.51 Pain Relevance 0.17
Prevention and delay in progression of human squamous cell carcinoma of the head and neck in nude mice by stable overexpression of the opioid growth factor receptor.
Positive_regulation (overexpression) of in head Gene_expression (overexpression) of opioid growth factor receptor in neck associated with skin cancer and opioid
20) Confidence 0.24 Published 2008 Journal Int. J. Oncol. Section Title Doc Link 18813788 Disease Relevance 0.84 Pain Relevance 0.20

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