INT13556

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 7
Speculated 4
Reported most in Body
Documents 367
Total Number 372
Disease Relevance 230.82
Pain Relevance 41.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cells 135
lymphocytes 20
regulatory T cells 10
blood 8
macrophages 7
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2591 100.00 Very High Very High Very High
addiction 562 100.00 Very High Very High Very High
Leflunomide 400 100.00 Very High Very High Very High
methadone 100 100.00 Very High Very High Very High
Inflammatory response 96 99.92 Very High Very High Very High
Inflammation 2799 99.88 Very High Very High Very High
rheumatoid arthritis 2460 99.84 Very High Very High Very High
Osteoarthritis 54 99.84 Very High Very High Very High
chemokine 513 99.66 Very High Very High Very High
Multiple sclerosis 333 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 9847 100.00 Very High Very High Very High
Disease 3105 100.00 Very High Very High Very High
Apoptosis 509 100.00 Very High Very High Very High
Lymphopenia 212 99.96 Very High Very High Very High
Cold Sores 652 99.94 Very High Very High Very High
INFLAMMATION 2925 99.88 Very High Very High Very High
Rheumatoid Arthritis 3060 99.84 Very High Very High Very High
Frailty 57 99.84 Very High Very High Very High
Malaria 151 99.80 Very High Very High Very High
Amebic Liver Abscess 186 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We present a rare case of adult T cell leukemia (ATL) in which leukemic T cells simultaneously expressed CD4 and CD8 surface antigens and refractory cytomegalovirus (CMV)-induced gastroenterocolitis preceded its clinical onset.
Gene_expression (expressed) of CD4 in T cell associated with t-cell leukemia, cytomegalovirus infection and htlv types i and ii
1) Confidence 0.78 Published 1999 Journal Int. J. Hematol. Section Abstract Doc Link 10071457 Disease Relevance 0.94 Pain Relevance 0.09
Unbound CD4-specific DARPin 57.2 was detectable in the plasma of macaques within 30 minutes after injection (Figure 2).
Gene_expression (detectable) of CD4 in plasma
2) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0 Pain Relevance 0
The functional importance of CD4 expression by these cell types and the precise role these cell types play during retroviral infection is not yet fully understood.
Gene_expression (expression) of CD4 associated with infection
3) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.50 Pain Relevance 0
In contrast, macaque CD123+ pDCs had higher levels of CD4 expression than monocytes or myeloid DCs [18] and consequently high levels of DARPin 57.2 binding.
Gene_expression (expression) of CD4 in monocytes
4) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.43 Pain Relevance 0
The results suggest that Tyr-MIF-1 does not directly modulate CD 2, CD 4 and CD 8 expression, does not alter the proliferative response of PBL, and does not affect the production of IL 2.
Gene_expression (expression) of CD 4 in PBL
5) Confidence 0.75 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2575445 Disease Relevance 0 Pain Relevance 0.34
Memory cells and other subsets were identified based on their expression of CD45RBbright/dull, CD45RA±, CD45RObright/dull, and CD62L± [24].


Gene_expression (expression) of CD4
6) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.12 Pain Relevance 0.03
Memory cells and other subsets were identified based on their expression of CD45RBbright/dull, CD45RA±, CD45RObright/dull, and CD62L± [24].


Gene_expression (expression) of CD4
7) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.12 Pain Relevance 0.03
METHODS: The levels of beta-endorphin, methionine-enkephalin, epinephrin, norepinephrin (NE), dopamine, corticotropin releasing factor (CRF), adrenocoricotropic hormone (ACTH), cortisol, CD4/CD8 ratio, CD57, NK cell activity and IL-6 in the peripheral blood, which are considered to reflect the activity of this neuroendocrine-immune network, were measured and compared between 49 patients with rheumatoid arthritis (RA) and 54 healthy control subjects.
Gene_expression (levels) of CD4 in blood
8) Confidence 0.75 Published 2000 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11072598 Disease Relevance 0.10 Pain Relevance 0
The concentrations of lymphocytes expressing the cluster designation (CD) cell-surface antigens CD3, CD4, CD8, and CD14 became elevated during exercise, and these responses were enhanced by hypoxia (P < or = 0.01).
Gene_expression (expressing) of CD4 in lymphocytes associated with hypoxia
9) Confidence 0.71 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 7759444 Disease Relevance 0.41 Pain Relevance 0.24
In the leflunomide group, there were significant decreases in frequency of both CD4 (Figure 4A) and CD8 (Figure 4B) T cells expressing CCR5 at Day 15 (CD4: ?
Gene_expression (expressing) of CD4 in T cells associated with leflunomide
10) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914784 Disease Relevance 0.09 Pain Relevance 0.16
Interpretation of the significance of a low CD4 lymphocyte count is problematic in a patient with coincident rheumatic fever and HIV infection as both conditions can cause CD4 lymphopenia.
Gene_expression (cause) of CD4 in lymphocyte associated with rheumatic fever, lymphopenia, acquired immune deficiency syndrome or hiv infection and infection
11) Confidence 0.68 Published 1991 Journal J. Infect. Section Abstract Doc Link 1673990 Disease Relevance 0.97 Pain Relevance 0.17
It is however generally accepted that 15 percent of HIV infected have CD4 counts less than 200/?
Gene_expression (counts) of CD4 associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.67 Published 2007 Journal Malar J Section Body Doc Link PMC2228308 Disease Relevance 1.30 Pain Relevance 0
Figure 3 clearly shows that the patient group with CD4+ counts between 51 and 100 cells/?
Gene_expression (counts) of CD4
13) Confidence 0.67 Published 2010 Journal Virol J Section Body Doc Link PMC2909198 Disease Relevance 1.44 Pain Relevance 0
The groups with CD4+ count less than 50 cells/?
Gene_expression (groups) of CD4
14) Confidence 0.67 Published 2010 Journal Virol J Section Body Doc Link PMC2909198 Disease Relevance 1.32 Pain Relevance 0
While an argument in favour of a lower CD4 threshold could be that these individuals would be eligible for ART once their CD4 count has descended to below 200 cells/?
Gene_expression (threshold) of CD4
15) Confidence 0.67 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.43 Pain Relevance 0
Delaying treatment until the CD4 count has fallen below 300-350 cells/?
Gene_expression (count) of CD4
16) Confidence 0.67 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.37 Pain Relevance 0
L, recent studies have raised concern about the risk of death from liver, renal, and heart diseases, as well as from "non-AIDS" cancers; incidence of these diseases is increased at lower CD4 counts, with significant differences seen between those with CD4 <350 cells/?
Gene_expression (counts) of CD4 in heart associated with cancer, heart disease, acquired immune deficiency syndrome or hiv infection, disease and death
17) Confidence 0.67 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.93 Pain Relevance 0
It is plausible that more women initiated HAART earlier in the HAART era when higher CD4 counts triggered the introduction of therapy.
Gene_expression (counts) of CD4
18) Confidence 0.67 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2875719 Disease Relevance 0.39 Pain Relevance 0
Mean CD4 counts increased to 413 cells/?
Gene_expression (counts) of CD4
19) Confidence 0.67 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2875719 Disease Relevance 0 Pain Relevance 0
Patients with CD4 counts between 200 and 350 were not regular in their treatments due to drop in their CD4 counts below 200 resulting in poor outcome.
Gene_expression (counts) of CD4
20) Confidence 0.67 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2918360 Disease Relevance 0.88 Pain Relevance 0

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