INT135568

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 6.51
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
fibroblasts 3
macrophage 1
liver 1
CHM (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 15 99.98 Very High Very High Very High
cytokine 30 98.76 Very High Very High Very High
Migraine 3 97.68 Very High Very High Very High
imagery 30 89.40 High High
cva 25 78.40 Quite High
anesthesia 18 61.88 Quite High
chemokine 5 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Choroideremia 830 100.00 Very High Very High Very High
Headache 14 99.98 Very High Very High Very High
Injury 10 99.34 Very High Very High Very High
Migraine Without Aura 1 98.20 Very High Very High Very High
Cancer 10 95.32 Very High Very High Very High
Necrosis 10 95.08 Very High Very High Very High
Adhesions 15 94.68 High High
Intracranial Embolism 3 93.52 High High
Heart Rate Under Development 10 92.40 High High
Sickle Cell Anemia 7 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This patient had clinical features of CHM (Fig. 2A); real time PCR analysis failed to show copy number variants of any of the exons of the CHM gene, but protein analysis confirmed absence of REP-1 (data not shown).
Localization (features) of CHM associated with choroideremia
1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.62 Pain Relevance 0
Finally, CHM fibroblasts secreted significantly lower levels of cytokine/growth factors such as macrophage chemoattractant protein-1 (MCP-1), pigment epithelial derived factor (PEDF), tumor necrosis factor (TNF) alpha, fibroblast growth factor (FGF) beta and interleukin (lL)-8.


Localization (secreted) of CHM in fibroblast associated with necrosis, cancer, choroideremia and cytokine
2) Confidence 0.61 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2793004 Disease Relevance 0.96 Pain Relevance 0.08
CHM fibroblasts secreted significantly lower levels of macrophage chemoattractant protein (MCP-1), pigment epithelial derived factor (PEDF), tumor necrosis factor (TNF) alpha, fibroblast growth factor (FGF) beta and interleukin (IL)-8 into the media.
Localization (secreted) of CHM in macrophage associated with necrosis, cancer and choroideremia
3) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.97 Pain Relevance 0
Primary fibroblasts from CHM patients released 3.2 fold less IL8, 4 fold less MCP1, 2.8 fold less TNF-alpha, 2.33 fold less FGF and 1.6 fold less of PEDF.
Localization (released) of CHM in fibroblasts associated with choroideremia
4) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.68 Pain Relevance 0.08
In contrast, fibroblasts from CHM patients, when compared to normal controls, secreted significantly lower levels of MCP-1, PEDF, TNF-alpha, FGF and IL-8.
Localization (secreted) of CHM in fibroblasts associated with choroideremia
5) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.74 Pain Relevance 0
Limitations to TCD routine utilization are represented by the need of a learning curve and some experience by the operators.
Localization (utilization) of TCD
6) Confidence 0.35 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.15 Pain Relevance 0.06
Patients with frequent and severe headache presented TCD velocities significantly higher than those without headache, or with milder headache.
Localization (presented) of TCD associated with headache
7) Confidence 0.21 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16686906 Disease Relevance 2.00 Pain Relevance 1.46
Comparably, CO was significantly correlated with both TCD and BFI.
Localization (correlated) of TCD
8) Confidence 0.12 Published 2006 Journal Crit Care Section Body Doc Link PMC1550846 Disease Relevance 0.21 Pain Relevance 0.07
Following liver trauma, CPP and CO as well as NIRS and TCD values decreased continuously.
Localization (decreased) of TCD in liver associated with injury
9) Confidence 0.12 Published 2006 Journal Crit Care Section Body Doc Link PMC1550846 Disease Relevance 0.19 Pain Relevance 0

General Comments

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