INT135578

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 28
Disease Relevance 11.71
Pain Relevance 8.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Prokr1) plasma membrane (Prokr1) signal transducer activity (Prokr1)
Anatomy Link Frequency
neurons 6
B cells 4
immune cell 2
testis 2
smooth muscle 1
Prokr1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 211 99.68 Very High Very High Very High
Inflammatory response 88 99.00 Very High Very High Very High
potassium channel 8 97.64 Very High Very High Very High
Pain 104 97.00 Very High Very High Very High
qutenza 250 96.52 Very High Very High Very High
cytokine 471 95.44 Very High Very High Very High
Hyperalgesia 52 93.60 High High
bradykinin 9 93.16 High High
Inflammation 262 91.72 High High
antagonist 28 87.08 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 211 99.68 Very High Very High Very High
Nociception 276 99.52 Very High Very High Very High
INFLAMMATION 338 98.64 Very High Very High Very High
Pain 103 97.00 Very High Very High Very High
Congenital Anomalies 7 95.84 Very High Very High Very High
Hematological Disease 39 95.76 Very High Very High Very High
Targeted Disruption 53 94.60 High High
Hyperalgesia 71 93.60 High High
Frailty 14 93.04 High High
Pressure And Volume Under Development 16 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many of the PKR1-expressing cells also expressed TRPV1 (Fig. 3A–C), although cells that expressed either PKR1 and TRPV1 were also evident.
Gene_expression (expressed) of PKR1
1) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.08 Pain Relevance 0.70
Two receptors for PK2, PKR1 and PKR2, are expressed in some DRG neurons, implying that PK2 may directly activate these PKRs-expressing neurons.
Gene_expression (expressed) of PKR1 in neurons associated with dorsal root ganglion
2) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.63 Pain Relevance 1.59
Our expression results also reveal that PKR1 is the dominant receptor expressed in primary nociceptive DRG neurons, consistent with the genetic study that mice lacking the PKR1 gene showed impaired response to capsaicin [13].
Gene_expression (expressed) of PKR1 in neurons associated with nociception, dorsal root ganglion and qutenza
3) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.22 Pain Relevance 0.83
Thus, PK2 may activate primary sensory neurons that express PKR1 and/or PKR2 via different signaling pathways.
Gene_expression (express) of PKR1 in primary sensory neurons
4) Confidence 0.70 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.41 Pain Relevance 0.57
Digoxigenin (DIG)-labeled PK2, PKR1 and PKR2 riboprobes and their sense control riboprobes were made using DIG RNA labeling mix from Roche.
Gene_expression (riboprobes) of PKR1
5) Confidence 0.61 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.07 Pain Relevance 0.03
In BMM, Prokr1 was transiently induced by LPS (37-fold at 6 h) but repressed in TEPM (20-fold at 7 h).
Gene_expression (repressed) of Prokr1
6) Confidence 0.58 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.44 Pain Relevance 0.07
Although both PKR1 and PKR2 are expressed in the DRG neurons, a recent report that mice lacking the PKR1 gene exhibit impaired pain perception to various stimuli including noxious heat, mechanical, capsaicin, and protons implies that PKR1 is likely to be the dominant receptor that exerts a tonic activation of TRPV1 [13].
Gene_expression (expressed) of PKR1 in neurons associated with pain, dorsal root ganglion and qutenza
7) Confidence 0.54 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.99 Pain Relevance 0.65
In situ hybridization with DIG-labeled riboprobe against PKR1 revealed its expression in many small DRG cells, likely neurons that are involved in nociception.
Gene_expression (expression) of PKR1 in neurons associated with nociception and dorsal root ganglion
8) Confidence 0.54 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.05 Pain Relevance 0.71
Since PKR1 and PKR2, two G-protein coupled receptors, co-express with TRPV1 in the DRG neurons, it is very likely that PK2 would also sensitize TRPV1 by activating PKRs.
Gene_expression (express) of PKR1 in neurons associated with dorsal root ganglion
9) Confidence 0.54 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.24 Pain Relevance 0.94
In particular, Dorsch et al. [18] have demonstrated the presence of both receptors on T and B lymphocytes, as well as on macrophages purified from murine spleen, and we have also shown [19] the high expression of PROKR 1 in murine peritoneal macrophages.
Gene_expression (expression) of PROKR in peritoneal macrophages
10) Confidence 0.47 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.07 Pain Relevance 0.07
Consistently with the data reported by Dorsch et al., [18], equal PROKR 1 and PROKR 2 expression appears to be present in T lymphocytes, while PROKR 2 is slightly more abundant in B cells.
Gene_expression (expression) of PROKR in B cells
11) Confidence 0.47 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.03
The highest PROKR expression was observed in CD11b+ cells.
Gene_expression (expression) of PROKR
12) Confidence 0.47 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.04
Consistently with the data reported by Dorsch et al., [18], equal PROKR 1 and PROKR 2 expression appears to be present in T lymphocytes, while PROKR 2 is slightly more abundant in B cells.
Gene_expression (expression) of PROKR in B cells
13) Confidence 0.47 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.03
Both PROKR 1 and 2 are more highly expressed in CD11b+ cells than in T and B lymphocytes; moreover in this cell type a predominance of PROKR 1 transcripts over PROKR 2 is found.
Gene_expression (expressed) of PROKR in B lymphocytes
14) Confidence 0.41 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.06 Pain Relevance 0.06
The expression of PROKR 1 and PROKR 2 in most murine immune cell types has been previously reported [18,19] however, we used real-time RT-PCR to confirm their presence in the splenocytes used in this study (Figure 1).
Gene_expression (expression) of PROKR in immune cell
15) Confidence 0.36 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.03
The expression of PROKR 1 and PROKR 2 in most murine immune cell types has been previously reported [18,19] however, we used real-time RT-PCR to confirm their presence in the splenocytes used in this study (Figure 1).
Gene_expression (expression) of PROKR in immune cell
16) Confidence 0.36 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0
Analysis of PROKR 1 and PROKR 2 expression in splenocytes
Gene_expression (expression) of PROKR
17) Confidence 0.36 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0
HT generated the PROKR 1 KO animals
Gene_expression (animals) of PROKR 1 KO
18) Confidence 0.35 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.29 Pain Relevance 0.23
RL performed some of the in vivo experiments and generated the PROKR 1 KO animals
Gene_expression (animals) of PROKR 1 KO
19) Confidence 0.35 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.29 Pain Relevance 0.23
Lower and similar expression of both receptors was found in CD3+ and in CD19+ cells, with a slight predominance of PROKR 2 in B lymphocytes.


Gene_expression (found) of PROKR in B lymphocytes
20) Confidence 0.35 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.07

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