INT135611

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.07
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CXCL1) signal transduction (CXCL1) extracellular space (CXCL1)
extracellular region (CXCL1) intracellular (CXCL1)
Anatomy Link Frequency
keratinocyte 2
CXCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 9 100.00 Very High Very High Very High
dexamethasone 2 97.44 Very High Very High Very High
ischemia 51 97.08 Very High Very High Very High
corticosteroid 3 96.88 Very High Very High Very High
Inflammation 60 93.68 High High
antagonist 2 91.44 High High
Inflammatory mediators 4 86.56 High High
Arthritis 2 75.00 Quite High
rheumatoid arthritis 3 65.96 Quite High
addiction 1 59.96 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 24 97.08 Very High Very High Very High
Stroke 27 96.56 Very High Very High Very High
Pressure And Volume Under Development 15 94.92 High High
INFLAMMATION 67 93.68 High High
Convulsion 15 93.20 High High
Body Weight 9 86.88 High High
Cv General 4 Under Development 24 83.48 Quite High
Disease 2 82.08 Quite High
Brain Hemorrhage 6 82.00 Quite High
Hypertension 9 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Candesartan reduced CXCL1 gene expression within the border of the ischemic lesion.
Negative_regulation (reduced) of Gene_expression (expression) of CXCL1 gene
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993950 Disease Relevance 1.07 Pain Relevance 0.25
Pretreatment with BQ-123 or BQ-788 (i.a.; 15 pmol/cavity) also decreased zymosan-induced TNF-alpha production within 6 h, keratinocyte-derived chemokine/CXCL1 production within 24 h, and leukotriene B(4) at both time-points.
Negative_regulation (decreased) of Gene_expression (production) of CXCL1 in keratinocyte associated with chemokine
2) Confidence 0.42 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18515326 Disease Relevance 1.13 Pain Relevance 0.53
In contrast, in the ischemic border zone there was a significant reduction of CXCL1 gene expression in animals treated with candesartan (p<0.01).
Negative_regulation (reduction) of Gene_expression (expression) of CXCL1 gene
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993950 Disease Relevance 0.44 Pain Relevance 0.03
Only aliskiren was able to reduce gene expression of CXCL1, interleukin-6 and TNF-alpha in the ischemic core.
Negative_regulation (reduce) of Gene_expression (expression) of CXCL1
4) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993950 Disease Relevance 1.01 Pain Relevance 0.22
As observed above, ICAM-1, IL-6, IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors.
Negative_regulation (reduced) of Gene_expression (expression) of GROalpha
5) Confidence 0.07 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 0.42 Pain Relevance 0.41

General Comments

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