INT135615

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 6.16
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IKBKB) nucleus (IKBKB) cytoplasm (IKBKB)
Anatomy Link Frequency
adipocytes 1
T cell 1
IKBKB (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 1 100.00 Very High Very High Very High
Inflammation 119 99.68 Very High Very High Very High
agonist 2 99.12 Very High Very High Very High
cINOD 2 96.76 Very High Very High Very High
tolerance 6 93.36 High High
cytokine 56 83.64 Quite High
corticosteroid 3 73.44 Quite High
Pain 6 58.80 Quite High
IPN 2 56.32 Quite High
rheumatoid arthritis 2 45.76 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 149 99.68 Very High Very High Very High
Adhesions 16 97.92 Very High Very High Very High
Cancer 37 97.24 Very High Very High Very High
Impaired Glucose Tolerance 6 94.72 High High
Hypertrophy 2 94.64 High High
Atherosclerosis 88 94.32 High High
Obesity 18 94.04 High High
Insulin Resistance 18 93.36 High High
Diabetes Mellitus 66 92.24 High High
Necrosis 11 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we have used adenoviral overexpression to demonstrate NF-kappaB and IKK2 dependence of key inflammatory genes, including intercellular adhesion molecule (ICAM)-1, cyclooxygenase-2, IL-6, IL-8, granulocyte macrophage-colony-stimulating factor (GM-CSF), regulated on activation normal T cell expressed and secreted (RANTES), monocyte chemotactic protein-1 (MCP-1), growth-regulated oncogene-alpha (GROalpha), neutrophil-activating protein-2 (NAP-2), and epithelial neutrophil activating peptide 78 (ENA-78) in primary human airways smooth muscle cells.
Positive_regulation (dependence) of IKK2 in T cell associated with addiction, inflammation and adhesions
1) Confidence 0.59 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 1.30 Pain Relevance 0.49
The polyphenols resveratrol and silibinin. inhibit or suppress the activation of IKKbeta [141].
Positive_regulation (activation) of IKKbeta
2) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 2.41 Pain Relevance 0.28
Isoflavones may improve lipid and glucose metabolism by acting as an antidiabetic PPAR agonist [140] The beta subunit of the signalsome – IKKbeta, a crucial catalyst of NF-kappaB activation – is an obligate mediator of the disruption of insulin signaling induced by excessive exposure of tissues to free fatty acids and by hypertrophy of adipocytes.
Positive_regulation (activation) of IKKbeta in adipocytes associated with hypertrophy, obesity and agonist
3) Confidence 0.04 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 1.88 Pain Relevance 0.12
Of the two catalytic subunits of IKK (IKKalpha and IKKbeta), low concentrations of NAC and mito-Q activated IKKalpha activity, thereby inhibiting the downstream NF-kappaB and ICAM-1 induction by TNF-alpha.
Positive_regulation (activated) of IKKbeta
4) Confidence 0.03 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.58 Pain Relevance 0.21

General Comments

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