INT135623

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn8a) plasma membrane (Scn8a) transmembrane transport (Scn8a)
Anatomy Link Frequency
neurons 2
Scn8a (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 1 75.00 Quite High
tetrodotoxin 1 63.44 Quite High
Disease Link Frequency Relevance Heat
Death 1 92.32 High High
Ataxia 1 85.92 High High
Tremor 1 85.28 High High
Targeted Disruption 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test the effect of cerebellar Na(V)1.6 on motor coordination in mice, we used the Cre-lox system to eliminate Scn8a expression exclusively in Purkinje neurons (Purkinje KO) and/or granule neurons (granule KO).
Positive_regulation (eliminate) of Gene_expression (expression) of Scn8a in neurons
1) Confidence 0.50 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16687615 Disease Relevance 0.34 Pain Relevance 0.10

General Comments

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