INT135625

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.74
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn8a) plasma membrane (Scn8a) transmembrane transport (Scn8a)
Anatomy Link Frequency
neuronal 1
arm 1
granule cells 1
Scn8a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 86.08 High High
sodium channel 2 75.00 Quite High
Inflammation 13 5.00 Very Low Very Low Very Low
Kinase C 9 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 40 99.34 Very High Very High Very High
Death 2 97.48 Very High Very High Very High
Tremor 2 96.80 Very High Very High Very High
Ataxia 2 96.48 Very High Very High Very High
Metabolic Syndrome 53 86.40 High High
Targeted Disruption 2 75.00 Quite High
Hyperlipidemia 6 50.00 Quite Low
Body Weight Changes 3 40.56 Quite Low
Weight Loss 8 16.24 Low Low
Cardiovascular Disease 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These disorders were exacerbated in double mutants lacking Scn8a in both Purkinje and granule cells (double KO).
Negative_regulation (lacking) of Scn8a in granule cells
1) Confidence 0.43 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16687615 Disease Relevance 0.35 Pain Relevance 0.12
Global null mutations that eliminate Scn8a in all cells result in severe motor dysfunction and premature death, precluding analysis of the physiological role of Na(V)1.6 in different neuronal types.
Negative_regulation (eliminate) of Scn8a in neuronal associated with death
2) Confidence 0.43 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16687615 Disease Relevance 0.30 Pain Relevance 0.04
There was an average 42.7% reduction in TG/HDL in the PED arm and only a 17.6% decrease in the MED arm.
Negative_regulation (decrease) of MED in arm associated with disorder of lipid metabolism
3) Confidence 0.02 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 1.10 Pain Relevance 0

General Comments

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