INT135629

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 33
Total Number 42
Disease Relevance 16.68
Pain Relevance 19.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
Anatomy Link Frequency
plasma 1
COMT (Homo sapiens)
COMT - V158M (3)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 1639 100.00 Very High Very High Very High
Pain 685 100.00 Very High Very High Very High
headache 9 100.00 Very High Very High Very High
Dopamine 350 99.96 Very High Very High Very High
Fibrositis 102 99.76 Very High Very High Very High
agonist 75 99.54 Very High Very High Very High
Face pain 8 99.52 Very High Very High Very High
Opioid 93 99.20 Very High Very High Very High
Catecholamine 93 99.20 Very High Very High Very High
Myofascial pain syndrome 2 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 16 100.00 Very High Very High Very High
Pain 688 99.80 Very High Very High Very High
Fibromyalgia 85 99.76 Very High Very High Very High
Facial Pain 8 99.52 Very High Very High Very High
Hantavirus Infection 626 99.38 Very High Very High Very High
Neurodegenerative Disease 17 99.16 Very High Very High Very High
Temporomandibular Joint Disorders 42 99.04 Very High Very High Very High
Hyperhomocysteinemia 16 98.86 Very High Very High Very High
Anxiety Disorder 252 98.80 Very High Very High Very High
Cardiovascular Disease 17 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For models in which a significant interaction was observed, a final round of regressions were conducted stratified by COMT genotype to determine the nature of the interaction between executive functioning and COMT on the particular sexual risk behavior.
COMT Binding (interaction) of
1) Confidence 0.48 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.19 Pain Relevance 0.03
In addition, results of our exploratory interaction analyses provide evidence that COMT genotype and executive dysfunction interact in models of number of sexual partners, condom use, insertive and receptive anal sex, as well as oral sex.
COMT Binding (interact) of
2) Confidence 0.48 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0 Pain Relevance 0
For example, Enoch et al. [9] found that COMT was only associated with HA amongst female but not male subjects.
COMT Binding (associated) of associated with catechol-o-methyltransferase
3) Confidence 0.48 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.09
It is apparent that the associations between COMT, executive dysfunction, and sexual risk behavior are highly complex and context dependent.
COMT Binding (associations) of
4) Confidence 0.42 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.07 Pain Relevance 0.13
However, for Trails B, significant interactions with COMT were observed for insertive (?
COMT Binding (interactions) of
5) Confidence 0.42 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0 Pain Relevance 0
Finally, the strongest interaction observed was between COMT and the Halstead Category Test for frequency of condom use.
COMT Binding (interaction) of
6) Confidence 0.42 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0 Pain Relevance 0
Applying an exploratory cut-off of P < .10, significant interactions between the executive functioning domain deficit score and COMT were observed for number of sexual partners (?
COMT Binding (interactions) of
7) Confidence 0.42 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2804107 Disease Relevance 0.07 Pain Relevance 0
In addition, sex, age of onset and family history were not associated with the COMT val(158)met polymorphism in this German population of RLS patients.
COMT (V158M) Binding (associated) of associated with catechol-o-methyltransferase and restless legs syndrome
8) Confidence 0.42 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20184941 Disease Relevance 0.95 Pain Relevance 0.51
In the present study, we examined the association between COMT genotype and specific pain-evoking stimuli.
COMT Spec (examined) Binding (association) of associated with pain and catechol-o-methyltransferase
9) Confidence 0.37 Published 2006 Journal Pain Section Abstract Doc Link 16837133 Disease Relevance 1.09 Pain Relevance 1.24
The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study.
catechol-O-methyltransferase (V158M) Binding (association) of associated with catechol-o-methyltransferase and headache
10) Confidence 0.37 Published 2006 Journal J Headache Pain Section Title Doc Link 16688411 Disease Relevance 0.60 Pain Relevance 1.00
Variation in the COMT gene: implications for pain perception and pain treatment.
COMT gene Binding (Variation) of associated with pain
11) Confidence 0.37 Published 2009 Journal Pharmacogenomics Section Title Doc Link 19374521 Disease Relevance 0.65 Pain Relevance 1.57
The association between Val/Met polymorphism at the COMT gene was evaluated in FM disorder.
COMT gene Binding (association) of associated with catechol-o-methyltransferase and fibrositis
12) Confidence 0.37 Published 2009 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 20074440 Disease Relevance 0.86 Pain Relevance 0.88
However, with repeated painful stimuli following this single opioid administration the mechanisms that are associated with the COMT val158met polymorphism can be manifested.
COMT Binding (associated) of associated with catechol-o-methyltransferase, pain and opioid
13) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695541 Disease Relevance 0.62 Pain Relevance 1.72
The same reaction in the presence of 15 mM EDTA was carried out in parallel for each lysate to bind Mg+2 ions required for COMT activity.
COMT Binding (bind) of associated with catechol-o-methyltransferase
14) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0 Pain Relevance 0.21
No significant association of gender with genotype or allele frequency of DRD2 and COMT was observed in either sample.
COMT Neg (No) Binding (association) of associated with catechol-o-methyltransferase
15) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.29
We found no significant interactions of DRD2 TaqI A1 allele × COMT Val allele for either HA or NS, within either sample (Table 1).
COMT Neg (no) Binding (interactions) of associated with catechol-o-methyltransferase
16) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.25
Gender had a significant effect on BIS scores, both as an independent variable and in association with the presence/absence of the COMT Met allele.
COMT Binding (association) of associated with catechol-o-methyltransferase
17) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.34
The presence of such minor SNPs in the major COMT haplotypes could be 1) compensatory, rescuing COMT activity by annulling the effects of their parent haplotypes [38], 2) neutral, carried with common selectively favored variants [39], or 3) deleterious, further reducing COMT activity through independent mechanisms or through interactions with other functional variants [40].
COMT Binding (interactions) of associated with catechol-o-methyltransferase
18) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.41 Pain Relevance 0.50
Similarly, there was no significant association of age and DRD2 or COMT.


COMT Neg (no) Binding (association) of associated with catechol-o-methyltransferase
19) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.27
No significant effect of DRD2 or COMT, either independently or as an interaction, on NS or HA scores was observed, within either sample.
COMT Binding (interaction) of associated with catechol-o-methyltransferase
20) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.21

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