INT135641

Context Info Confidence 0.35 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.34 Pain Relevance 0.06

cell differentiation (Ina) nuclear envelope (Dst) endoplasmic reticulum (Dst) cytoplasm (Dst) structural molecule activity (Ina) cell motility (Dst)

Anatomy Link Frequency neuronal 1 Dst (Mus musculus) Ina (Mus musculus)

Pain Link Frequency Relevance Heat Hsan 1 59.56

Disease Link Frequency Relevance Heat Neurodegenerative Disease 1 92.60 Dystonia 2 75.00 Bullous Skin Disease 1 60.84 Hereditary Sensory And Autonomic Neuropathies 1 59.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

From our observations, we suggest that the interaction between BPAG1 and alpha-internexin may be one of the key factors involved in neuronal degeneration, and abnormal accumulation of alpha-internexin may impair the axonal transport and subsequently turns on the cascade of neuronal apoptosis in dt mice.

BPAG1 Binding (interaction) of alpha-internexin in neuronal associated with neurodegenerative disease

1) Confidence 0.35 Published 2006 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 16691115 Disease Relevance 0.34 Pain Relevance 0.06

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