INT135644

Context Info Confidence 0.19 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 2.60 Pain Relevance 0.22

cytosol (Aco1) mitochondrion (Aco1) lyase activity (Aco1) Golgi apparatus (Aco1) endoplasmic reticulum (Aco1) RNA binding (Aco1)

Anatomy Link Frequency neuronal 1 Aco1 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 2 93.52 abdominal pain 1 78.72 hyperexcitability 1 71.04 midbrain 36 60.00 Inflammation 2 5.00 Pain 2 5.00 addiction 2 5.00 Substantia nigra 2 5.00

Disease Link Frequency Relevance Heat Aging 2 99.48 Toxicity 8 96.76 Parkinson's Disease 22 96.40 Alzheimer's Dementia 2 94.28 Cv General 4 Under Development 2 93.52 Death 118 91.32 Stress 24 91.12 Epilepsy 2 84.96 Ataxia 2 83.84 Supranuclear Palsy 2 83.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our data demonstrate that oxidative inactivation of m-aconitase results in the formation of Fenton reactants in neuronal cells which provides evidence for the pathogenic mechanism in which m-aconitase not only serves as a target but also as a source of oxidants.

m-aconitase Binding (target) of in neuronal

1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.56 Pain Relevance 0

Aconitase has been widely recognized as a sensitive and relatively specific target of ROS, particularly O2.?.

Aconitase Binding (recognized) of

2) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 1.58 Pain Relevance 0.10

The toxic effects of SFAC are caused by fluorocitrate action, a toxic metabolite, which has a competitive action with aconitase enzyme, leading to citrate accumulation and resulting in interference in energy production by Krebs cycle blockade.

aconitase enzyme Binding (action) of

3) Confidence 0.03 Published 2006 Journal Hum Exp Toxicol Section Abstract Doc Link 16696292 Disease Relevance 0.46 Pain Relevance 0.11

General Comments

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