INT135658

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.39
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
DRG 1
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 8 98.74 Very High Very High Very High
dorsal root ganglion 7 98.30 Very High Very High Very High
substance P 11 97.68 Very High Very High Very High
b2 receptor 1 96.72 Very High Very High Very High
qutenza 6 87.04 High High
Root ganglion neuron 1 75.00 Quite High
Inflammation 4 60.00 Quite High
COX2 2 25.00 Low Low
Pain 2 25.00 Low Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 98.30 Very High Very High Very High
Injury 20 87.72 High High
Diabetes Mellitus 22 83.80 Quite High
Neointima 6 82.72 Quite High
Hyperplasia 5 81.92 Quite High
Vasculitis 5 60.00 Quite High
Atherosclerosis 9 58.12 Quite High
Cardiovascular Disease 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the long-term exposure of DRG neurons to bradykinin (3 h) resulted in extracellular signal-regulated kinase (ERK) phosphorylation at an early stage and thereafter induced cyclooxygenase-2 (COX-2) protein expression, which both contribute to the SP release triggered by bradykinin B2 receptor.
Phosphorylation (phosphorylation) of cyclooxygenase-2 in DRG associated with dorsal root ganglion, b2 receptor, bradykinin and substance p
1) Confidence 0.23 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16696851 Disease Relevance 0.58 Pain Relevance 1.31
Alagebrium dose-dependently inhibited AGE-mediated formation of reactive oxygen species (ROS), extracellular signal-regulated kinase phosphorylation, and cyclooxygenase-2 expression.
Phosphorylation (phosphorylation) of cyclooxygenase-2
2) Confidence 0.13 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2978295 Disease Relevance 0.82 Pain Relevance 0.03

General Comments

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