INT135667

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.22
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a) cytoplasm (Camk2a)
Anatomy Link Frequency
neural 2
Camk2a (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 99.96 Very High Very High Very High
Delta opioid receptors 2 96.48 Very High Very High Very High
addiction 17 76.20 Quite High
agonist 4 75.08 Quite High
opioid receptor 4 75.00 Quite High
Kappa opioid receptor 1 74.76 Quite High
Enkephalin 1 72.96 Quite High
gABA 11 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 3 92.80 High High
Ganglion Cysts 14 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of autophosphorylation at Thr286/287 on CaMKII activation peaked rapidly during the [Ca2+]i increase, whereas that of PDE1 inhibition became stronger about 100 s after the [Ca2+]i increase (Figure 5G; Supplementary Figure 4), when the decrease of CaMKII activity was suppressed.
Negative_regulation (suppressed) of Negative_regulation (decrease) of CaMKII
1) Confidence 0.42 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
The SNC80-induced neural differentiation was also inhibited by treatment with the protein kinase C (PKC) inhibitor, phosphatidylinositol 3-kinase (PI3K) inhibitor, mitogen-activated protein kinase kinase (MEK) inhibitor or Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of CaMKII in neural associated with kinase c
2) Confidence 0.38 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16696856 Disease Relevance 0.22 Pain Relevance 0.56
Third, decreasing CaMKII levels reduced both the weight of pCaMKII puncta and the strength of CREB signaling.
Negative_regulation (reduced) of Negative_regulation (decreasing) of CaMKII
3) Confidence 0.24 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.04

General Comments

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