INT135668

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pik3cd) signal transduction (Pik3cd) kinase activity (Pik3cd)
Anatomy Link Frequency
neural 2
Pik3cd (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 99.96 Very High Very High Very High
cytokine 5 90.72 High High
Delta opioid receptors 2 86.64 High High
agonist 4 75.08 Quite High
opioid receptor 4 75.00 Quite High
Kappa opioid receptor 1 74.76 Quite High
Enkephalin 1 72.96 Quite High
Inflammatory stimuli 2 35.44 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 7 82.96 Quite High
Disease 58 82.24 Quite High
Stress 3 50.00 Quite Low
INFLAMMATION 19 35.08 Quite Low
Death 8 5.00 Very Low Very Low Very Low
Amyloid Plaque 7 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 5 5.00 Very Low Very Low Very Low
Neutrophil Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SNC80-induced neural differentiation was also inhibited by treatment with the protein kinase C (PKC) inhibitor, phosphatidylinositol 3-kinase (PI3K) inhibitor, mitogen-activated protein kinase kinase (MEK) inhibitor or Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of phosphatidylinositol 3-kinase in neural associated with kinase c
1) Confidence 0.13 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16696856 Disease Relevance 0.21 Pain Relevance 0.55
Furthermore, global inhibition of src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production.
Negative_regulation (inhibition) of Negative_regulation (inhibition) of phosphatidylinositol-3 kinase
2) Confidence 0.04 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.08 Pain Relevance 0.05

General Comments

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