INT135672

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.33
Pain Relevance 5.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a3)
Anatomy Link Frequency
astrocytes 2
Slc1a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 42 100.00 Very High Very High Very High
Glutamate 40 100.00 Very High Very High Very High
Endep 31 100.00 Very High Very High Very High
Inflammation 6 100.00 Very High Very High Very High
cytokine 3 100.00 Very High Very High Very High
Antinociceptive 8 98.00 Very High Very High Very High
intrathecal 9 97.96 Very High Very High Very High
tolerance 4 96.40 Very High Very High Very High
Spinal cord 6 92.80 High High
excitatory amino acid 8 87.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 100.00 Very High Very High Very High
Nervous System Injury 13 85.20 High High
Injury 3 77.84 Quite High
Hypersensitivity 4 16.80 Low Low
Nociception 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanisms involved may include: (a) inhibition of pro-inflammatory cytokine expression, (b) prevention of glutamate transporter down-regulation, and even up-regulation of glial GTs GLAST and GLT-1 expression, with (c) attenuation of morphine-evoked EAA release following continuous long-term morphine infusion.
Negative_regulation (inhibition) of Positive_regulation (up-regulation) of GLAST associated with glutamate, inflammation, morphine and cytokine
1) Confidence 0.38 Published 2006 Journal Pain Section Abstract Doc Link 16697108 Disease Relevance 0.10 Pain Relevance 1.95
Daily intrathecal injection of Ro106-9920 prevented the amitriptyline/morphine-induced NF-kappaB p65 translocation and reversed the amitriptyline/morphine-induced GLAST and GLT-1 upregulation and inhibited the restoration of EAAC1 expression.
Negative_regulation (reversed) of Positive_regulation (upregulation) of GLAST associated with endep, morphine and intrathecal
2) Confidence 0.35 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.73
Daily intrathecal injection of Ro106-9920 prevented the amitriptyline/morphine-induced NF-kappaB p65 translocation and reversed the amitriptyline/morphine-induced GLAST and GLT-1 upregulation and inhibited the restoration of EAAC1 expression.
Negative_regulation (reversed) of Positive_regulation (induced) of GLAST associated with endep, morphine and intrathecal
3) Confidence 0.35 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.72
The results from the above suggest that the decrease in GLT-1 and GLAST, which was induced by PNSL, mainly occurred in astrocytes on the injured side.


Negative_regulation (decrease) of Positive_regulation (induced) of GLAST in astrocytes
4) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.23 Pain Relevance 0.08

General Comments

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